Alternative titles; symbols
HGNC Approved Gene Symbol: IFI27
Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:94,105,894-94,116,690 (from NCBI)
Rasmussen et al. (1993) isolated a novel cDNA, which they called p27, from estradiol-treated human breast carcinoma cells. It encoded a putative highly hydrophobic protein of 122 amino acids that had a 33% overall sequence similarity to the product of the interferon-induced protein IFI-6-16 (IFI616; 147572). The latter gene is transcriptionally induced by interferons of the alpha (see 147660) and beta (see 147640) type. Rasmussen et al. (1993) showed that the IFI27 gene also is induced by interferon-alpha in human cell lines of different origin and that expression is independent of the presence of estradiol receptor in the cells.
Rasmussen et al. (1993) mapped the IFI27 gene to chromosome 14q32 by isotopic in situ hybridization.
Rasmussen, U. B., Wolf, C., Mattei, M.-G., Chenard, M.-P., Bellocq, J.-P., Chambon, P., Rio, M.-C., Basset, P. Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma. Cancer Res. 53: 4096-4101, 1993. [PubMed: 8358738]