Entry - *600070 - URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASE 2 FAMILY, MEMBER B10; UGT2B10 - OMIM

 
 
* 600070

URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASE 2 FAMILY, MEMBER B10; UGT2B10


Alternative titles; symbols

UDP GLYCOSYLTRANSFERASE 2 FAMILY, MEMBER B10
UDP GLUCURONOSYLTRANSFERASE 2 FAMILY, MEMBER B10


HGNC Approved Gene Symbol: UGT2B10

Cytogenetic location: 4q13.2     Genomic coordinates (GRCh38): 4:68,815,994-68,832,023 (from NCBI)


TEXT

▼ Description

The UGT2B10 gene encodes a member of the UGT family (EC 2.4.1.17), which are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (summary by Jin et al., 1993). See UGT2B4 (600067).


▼ Cloning and Expression

By screening a liver library with a rat UGT2B1 cDNA, Jin et al. (1993) isolated cDNAs encoding UGT2B4, which they called UGT2B11, and UGT2B10. The predicted 528-amino acid UGT2B10 protein contained an N-terminal signal peptide and a C-terminal transmembrane hydrophobic region. Mammalian cells expressing UGT2B10 produced a 49-kD protein that was recognized by a UGT-specific polyclonal antibody. However, the expressed protein exhibited no glucuronidation activity towards more than 40 xenobiotics and steroids tested.


▼ Mapping

Gross (2014) mapped the UGT2B10 gene to chromosome 4q13.2 based on an alignment of the UGT2B10 sequence (GenBank BC113649) with the genomic sequence (GRCh38).

▼ REFERENCES

  1. Gross, M. B. Personal Communication. Baltimore, Md. 7/28/2014.

  2. Jin, C.-J., Miners, J. O., Lillywhite, K. J., Mackenzie, P. I. cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. Biochem. Biophys. Res. Commun. 194: 496-503, 1993. [PubMed: 8333863, related citations] [Full Text]


Contributors:
Matthew B. Gross - updated : 07/28/2014
Rebekah S. Rasooly - updated : 6/22/1998
Creation Date:
Victor A. McKusick : 8/3/1994
Edit History:
mgross : 07/28/2014
alopez : 3/26/2014
mcapotos : 4/6/2000
alopez : 7/7/1998
alopez : 6/22/1998
alopez : 5/20/1998
alopez : 5/20/1998
terry : 8/4/1994
terry : 8/3/1994

* 600070

URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASE 2 FAMILY, MEMBER B10; UGT2B10


Alternative titles; symbols

UDP GLYCOSYLTRANSFERASE 2 FAMILY, MEMBER B10
UDP GLUCURONOSYLTRANSFERASE 2 FAMILY, MEMBER B10


HGNC Approved Gene Symbol: UGT2B10

Cytogenetic location: 4q13.2     Genomic coordinates (GRCh38): 4:68,815,994-68,832,023 (from NCBI)


TEXT

Description

The UGT2B10 gene encodes a member of the UGT family (EC 2.4.1.17), which are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (summary by Jin et al., 1993). See UGT2B4 (600067).


Cloning and Expression

By screening a liver library with a rat UGT2B1 cDNA, Jin et al. (1993) isolated cDNAs encoding UGT2B4, which they called UGT2B11, and UGT2B10. The predicted 528-amino acid UGT2B10 protein contained an N-terminal signal peptide and a C-terminal transmembrane hydrophobic region. Mammalian cells expressing UGT2B10 produced a 49-kD protein that was recognized by a UGT-specific polyclonal antibody. However, the expressed protein exhibited no glucuronidation activity towards more than 40 xenobiotics and steroids tested.


Mapping

Gross (2014) mapped the UGT2B10 gene to chromosome 4q13.2 based on an alignment of the UGT2B10 sequence (GenBank BC113649) with the genomic sequence (GRCh38).

REFERENCES

  1. Gross, M. B. Personal Communication. Baltimore, Md. 7/28/2014.

  2. Jin, C.-J., Miners, J. O., Lillywhite, K. J., Mackenzie, P. I. cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. Biochem. Biophys. Res. Commun. 194: 496-503, 1993. [PubMed: 8333863] [Full Text: https://doi.org/10.1006/bbrc.1993.1847]


Contributors:
Matthew B. Gross - updated : 07/28/2014
Rebekah S. Rasooly - updated : 6/22/1998

Creation Date:
Victor A. McKusick : 8/3/1994

Edit History:
mgross : 07/28/2014
alopez : 3/26/2014
mcapotos : 4/6/2000
alopez : 7/7/1998
alopez : 6/22/1998
alopez : 5/20/1998
alopez : 5/20/1998
terry : 8/4/1994
terry : 8/3/1994



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 7, 2024