Alternative titles; symbols
HGNC Approved Gene Symbol: GRIK5
Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,998,324-42,070,206 (from NCBI)
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. Its physiologic action is exerted through the activation of ligand-gated ion channels and G protein-coupled membrane receptors. Glutamate-gated ionic channels are broadly classified into N-methyl-D-aspartate (NMDA) and non-NMDA types. Three related non-NMDA receptor subunit gene families have been defined: the AMPA-preferring family, e.g., GLUR1 (138248), and the 2 kainate-preferring families. GRIK1 (138245), GRIK2 (138244), and GRIK3 (138243) constitute one of the GRIK gene families, and KA1 (GRIK4; 600282) and KA2 (GRIK5; 600283) constitute the second GRIK gene family. GRIK4 and GRIK5 form functional heteromeric kainate-preferring ionic channels with the subunits encoded by the GRIK1, GRIK2, and GRIK3 genes, but not with those falling in the AMP-preferring family (Szpirer et al., 1994).
GRIK4 and GRIK5 display 68% identity in their amino acid sequence (Szpirer et al., 1994).
The chromosomal localization of the human and rat genes encoding the kainate-preferring glutamate receptor subunit GRIK5 was determined by Southern analysis of rat/mouse and human/mouse somatic cell hybrid panels and by fluorescence in situ hybridization. The localization of the mouse Grik5 gene was established by interspecific backcross mapping. GRIK5 was found to be located on human 19q13.2, mouse chromosome 7, and rat chromosome 1 (Szpirer et al., 1994).
Szpirer, C., Molne, M., Antonacci, R., Jenkins, N. A., Finelli, P., Szpirer, J., Riviere, M., Rocchi, M., Gilbert, D. J., Copeland, N. G., Gallo, V. The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. Proc. Nat. Acad. Sci. 91: 11849-11853, 1994. [PubMed: 7527545] [Full Text: https://doi.org/10.1073/pnas.91.25.11849]