Alternative titles; symbols
HGNC Approved Gene Symbol: RGS1
Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:192,575,773-192,580,024 (from NCBI)
The processes of induced proliferation and differentiation in mammalian cell types are preceded by the rapid induction of a complex set of immediate-early response genes (ERG) whose products may mediate programmed changes in the cell in response to extracellular signals. Newton et al. (1993) determined the cDNA sequence of a human B-cell specific immediate early gene, which they designated 1R20, that is inducible in response to several B-cell activation signals. The cDNA sequence predicted a 196-amino acid protein. See also RGS2 (600861).
Sierra et al. (2002) determined that the RGS1 gene contains 4 exons and spans 4.1 kb.
By fluorescence in situ hybridization, Newton et al. (1993) localized the 1R20 gene to 1q31, a region known to be implicated in the pathogenesis of hemopoietic malignancies.
For discussion of a possible association between variation in the RGS1 gene and celiac disease, see CELIAC7 (612005).
Newton, J. S., Deed, R. W., Mitchell, E. L. D., Murphy, J. J., Norton, J. D. A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein. Biochim. Biophys. Acta 1216: 314-316, 1993. [PubMed: 8241276] [Full Text: https://doi.org/10.1016/0167-4781(93)90163-8]
Sierra, D. A., Gilbert, D. J., Householder, D., Grishin, N. V., Yu, K., Ukidwe, P., Barker, S. A., He, W., Wensel, T. G., Otero, G., Brown, G., Copeland, N. G., Jenkins, N. A., Wilkie, T. M. Evolution of the regulators of G-protein signaling multigene family in mouse and human. Genomics 79: 177-185, 2002. [PubMed: 11829488] [Full Text: https://doi.org/10.1006/geno.2002.6693]