Alternative titles; symbols
HGNC Approved Gene Symbol: GCNT1
Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:76,393,869-76,507,416 (from NCBI)
Bierhuizen et al. (1993) provided the sequence of the developmental I antigen encoded by the cDNA for a member of a beta-1,6-N-acetylglucosaminyltransferase gene family.
By Northern blot analysis, Yeh et al. (1999) showed that multiple transcripts of GCNT1 were expressed in nearly all tissues tested, whereas expression of GCNT3 (606836) was more restricted. Transcripts were also readily detected in some leukemic cell lines and in colon and cervical carcinoma cell lines, but not in a lung carcinoma cell line.
The GCNT1 gene was found by isotopic in situ hybridization (Bierhuizen et al., 1993) to map to 9q21 in the human and by genetic linkage study to map to chromosome 13 in the mouse (Pilz et al., 1995).
Yeh et al. (1999) mapped the GCNT1 gene to chromosome 9q13 by PCR and radiation hybrid analysis.
Bierhuizen, M. F. A., Mattei, M.-G., Fukuda, M. Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family. Genes Dev. 7: 468-478, 1993. [PubMed: 8449405] [Full Text: https://doi.org/10.1101/gad.7.3.468]
Pilz, A., Woodward, K., Povey, S., Abbott, C. Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse. Genomics 25: 139-149, 1995. [PubMed: 7774911] [Full Text: https://doi.org/10.1016/0888-7543(95)80119-7]
Yeh, J.-C., Ong, E., Fukuda, M. Molecular cloning and expression of a novel beta-1,6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches. J. Biol. Chem. 274: 3215-3221, 1999. [PubMed: 9915862] [Full Text: https://doi.org/10.1074/jbc.274.5.3215]