HGNC Approved Gene Symbol: GPR6
Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:109,978,311-109,980,720 (from NCBI)
Many cell membrane receptors are members of the G protein-coupled receptor family which are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. Using degenerate PCR, Heiber et al. (1995) identified additional members of this family, one of which was designated GPR6. A genomic DNA library was screened with the GPR6 PCR-based probe. The characterized gene encoded a putative 362-amino acid protein. Northern blots showed abundant expression in the putamen of the brain and, to a lesser extent, in the frontal cortex, hippocampus, and hypothalamus.
Song et al. (1995) demonstrated that this receptor protein contains 363 amino acids.
Heiber et al. (1995) and Song et al. (1995) determined that the GPR6 gene consists of a single exon.
By fluorescence in situ hybridization, Song et al. (1995) mapped the GPR6 gene to chromosome 6q21.
Heiber, M., Docherty, J. M., Shah, G., Nguyen, T., Cheng, R., Heng, H. H. Q., Marchese, A., Tsui, L.-C., Shi, X., George, S. R., O'Dowd, B. F. Isolation of three novel human genes encoding G protein-coupled receptors. DNA Cell Biol. 14: 25-35, 1995. [PubMed: 7832990] [Full Text: https://doi.org/10.1089/dna.1995.14.25]
Song, Z.-H., Modi, W., Bonner, T. I. Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. Genomics 28: 347-349, 1995. [PubMed: 8530049] [Full Text: https://doi.org/10.1006/geno.1995.1154]