Entry - *600690 - T-CELL LEUKEMIA TRANSLOCATION-ASSOCIATED GENE; TCTA - OMIM

 
 
* 600690

T-CELL LEUKEMIA TRANSLOCATION-ASSOCIATED GENE; TCTA


HGNC Approved Gene Symbol: TCTA

Cytogenetic location: 3p21.31     Genomic coordinates (GRCh38): 3:49,412,423-49,416,476 (from NCBI)


TEXT

▼ Cloning and Expression

Aplan et al. (1995) cloned a gene at the site of a t(1;3)(p34;p21) translocation breakpoint in T-cell acute lymphoblastic leukemia. A cDNA for the gene, designated TCTA (T-cell leukemia translocation-associated gene), was identified from a human bone marrow library. The cDNA has a short open reading frame of 103 amino acids. Northern blots showed that the gene was expressed ubiquitously with highest levels in the kidney. The TCTA gene is deleted in a subset of small cell lung cancer (SCLC) cell lines. By comparative Southern blot analysis, the authors detected related sequences in the DNA of other mammals, chicken, and Drosophila.


▼ Mapping

Aplan et al. (1995) identified the TCTA gene at chromosome 3p21 by analysis of a translocation breakpoint.


▼ REFERENCES

  1. Aplan, P. D., Johnson, B. E., Russell, E., Chervinsky, D. S., Kirsch, I. R. Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. Cancer Res. 55: 1917-1921, 1995. [PubMed: 7728759, related citations]


Creation Date:
Alan F. Scott : 7/27/1995
Edit History:
alopez : 04/16/2014
joanna : 5/8/1998
mimadm : 11/3/1995
mark : 7/27/1995

* 600690

T-CELL LEUKEMIA TRANSLOCATION-ASSOCIATED GENE; TCTA


HGNC Approved Gene Symbol: TCTA

Cytogenetic location: 3p21.31     Genomic coordinates (GRCh38): 3:49,412,423-49,416,476 (from NCBI)


TEXT

Cloning and Expression

Aplan et al. (1995) cloned a gene at the site of a t(1;3)(p34;p21) translocation breakpoint in T-cell acute lymphoblastic leukemia. A cDNA for the gene, designated TCTA (T-cell leukemia translocation-associated gene), was identified from a human bone marrow library. The cDNA has a short open reading frame of 103 amino acids. Northern blots showed that the gene was expressed ubiquitously with highest levels in the kidney. The TCTA gene is deleted in a subset of small cell lung cancer (SCLC) cell lines. By comparative Southern blot analysis, the authors detected related sequences in the DNA of other mammals, chicken, and Drosophila.


Mapping

Aplan et al. (1995) identified the TCTA gene at chromosome 3p21 by analysis of a translocation breakpoint.


REFERENCES

  1. Aplan, P. D., Johnson, B. E., Russell, E., Chervinsky, D. S., Kirsch, I. R. Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. Cancer Res. 55: 1917-1921, 1995. [PubMed: 7728759]


Creation Date:
Alan F. Scott : 7/27/1995

Edit History:
alopez : 04/16/2014
joanna : 5/8/1998
mimadm : 11/3/1995
mark : 7/27/1995



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 1, 2024