Alternative titles; symbols
HGNC Approved Gene Symbol: IFI35
Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,006,784-43,014,456 (from NCBI)
Interferons ( e.g., 147660) affect cellular functions by altering the expression of a number of specific genes. Bange et al. (1994) reported a human cDNA, designated IFP35 by them (interferon-inducible protein of 35 kD), which they cloned from interferon-gamma (147570)-induced HeLa cell mRNA screened by differential hybridization. The cDNA encodes a 282-amino acid predicted protein containing a leucine zipper motif at the amino terminus. Unlike most other leucine zipper proteins, IFP35 lacks a basic domain associated with DNA binding. Bange et al. (1994) found that in vitro translation of IFP35 mRNA resulted in the synthesis of a 35-kD protein. Northern blots showed that the 1.4-kb IFP35 mRNA occurs in fibroblasts, macrophages, and epithelial cells following interferon treatment. Western blots indicated that the IFP35 gene product can form homodimers and that there was increased nuclear localization following interferon treatment.
Brown et al. (1995), as part of an effort to clone the BRCA1 gene (113705), used exon trapping to identify genes in a 500-kb region on 17q21. Among the exons identified from a phage P1 artificial chromosome (PAC) that included regions from BRCA1 were several coding regions with 100% identity to IFP35. Smith et al. (1996) likewise found the IFP35 gene situated centromeric to the BRCA1 gene in the course of sequencing and analyzing 117 kb of DNA from the 17q21 region.
Bange, F.-C., Vogel, U., Flohr, T., Kiekenbeck, M., Denecke, B., Boettger, E. C. IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution. J. Biol. Chem. 269: 1091-1098, 1994. [PubMed: 8288566]
Brown, M. A., Jones, K. A., Nicolai, H., Bonjardim, M., Black, D., McFarlane, R., De Jong, P., Quirk, J. P., Lehrach, H., Solomon, E. Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1. Proc. Nat. Acad. Sci. 92: 4362-4366, 1995. [PubMed: 7753812] [Full Text: https://doi.org/10.1073/pnas.92.10.4362]
Smith, T. M., Lee, M. K., Szabo, C. I., Jerome, N., McEuen, M., Taylor, M., Hood, L., King, M.-C. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. Genome Res. 6: 1029-1049, 1996. [PubMed: 8938427] [Full Text: https://doi.org/10.1101/gr.6.11.1029]