HGNC Approved Gene Symbol: SYT5
Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,171,196-55,180,289 (from NCBI)
Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995).
Hudson and Birnbaum (1995) cloned a Syt5 cDNA from a rat adipose tissue cDNA library. The predicted 386-amino acid protein shares 49% identity with synaptotagmin-1 (185605) and -2 (600104). The 1.7-kb Syt5 mRNA was expressed in rat kidney, adipose tissue, lung, and heart, with higher levels in brain. An antibody to the Syt5 gene product detected an approximately 50-kD protein.
Kwon et al. (1995) mapped the Syt5 gene to mouse chromosome 7 and predicted that the human gene is located on chromosome 11p. However, Gross (2011) mapped the human SYT5 gene to chromosome 19q13.42 based on an alignment of the SYT5 sequence (GenBank BC046157) with the genomic sequence (GRCh37).
Gross, M. B. Personal Communication. Baltimore, Md. 2/9/2011.
Hudson, A. W., Birnbaum, M. J. Identification of a nonneuronal isoform of synaptotagmin. Proc. Nat. Acad. Sci. 92: 5895-5899, 1995. [PubMed: 7597049] [Full Text: https://doi.org/10.1073/pnas.92.13.5895]
Kwon, O.-J., Adamson, M. C., Chin, H., Kozak, C. A. Genetic mapping of five mouse genes encoding synaptotagmins. Mammalian Genome 6: 880-881, 1995. [PubMed: 8747928] [Full Text: https://doi.org/10.1007/BF00292439]