Alternative titles; symbols
HGNC Approved Gene Symbol: ELOC
Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:73,945,119-73,972,287 (from NCBI)
The elongin (SIII) complex is a heterotrimer composed of 3 subunits, called elongin A (ELOA; 600786), B (ELOB; 600787), and C, of 110, 18, and 15 kD, respectively. Aso et al. (1995) demonstrated that the 110-kD polypeptide designated elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits.
Garrett et al. (1994) isolated and sequenced the human ELOC gene (which they had referred to as p15).
Duan et al. (1995) and Kibel et al. (1995) reported results suggesting that the tumor suppression activity of the von Hippel-Lindau tumor suppressor gene product (608537) is a function of its ability to bind to elongins B and C and thereby inhibit transcription elongation.
The International Radiation Hybrid Mapping Consortium mapped the ELOC gene to chromosome 8 (stSG4816).
Pseudogene
A gene designated TCEB1L because of its high sequence similarity to TCEB1 was later found to be the same as OCP2 (SKP1A; 601434), which maps to chromosome 5. Demetrick et al. (1996) mapped the SKP1A gene to 7q11.2 by fluorescence in situ hybridization, but this was later determined to be a pseudogene (SKP1P1).
Aso, T., Lane, W. S., Conaway, J. W., Conaway, R. C. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. Science 269: 1439-1443, 1995. [PubMed: 7660129] [Full Text: https://doi.org/10.1126/science.7660129]
Demetrick, D. J., Zhang, H., Beach, D. H. Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2). Cytogenet. Cell Genet. 73: 104-107, 1996. [PubMed: 8646875] [Full Text: https://doi.org/10.1159/000134318]
Duan, D. R., Pause, A., Burgess, W. H., Aso, T., Chen, D. Y. T., Garrett, K. P., Conaway, R. C., Conaway, J. W., Linehan, W. M., Klausner, R. D. Inhibition of transcription elongation by the VHL tumor suppressor protein. Science 269: 1402-1406, 1995. [PubMed: 7660122] [Full Text: https://doi.org/10.1126/science.7660122]
Garrett, K. P., Haque, D., Conaway, R. C., Conaway, J. W. A human cDNA encoding the small subunit of RNA polymerase II transcription factor SIII. Gene 150: 413-414, 1994. [PubMed: 7821821] [Full Text: https://doi.org/10.1016/0378-1119(94)90467-7]
Kibel, A., Iliopoulos, O., DeCaprio, J. A., Kaelin, W. G., Jr. Binding of the von Hippel-Lindau tumor suppressor protein to elongin B and C. Science 269: 1444-1446, 1995. [PubMed: 7660130] [Full Text: https://doi.org/10.1126/science.7660130]