Alternative titles; symbols
HGNC Approved Gene Symbol: MRPL23
Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,947,332-2,014,944 (from NCBI)
The closely linked insulin growth factor-2 (IGF2; 147470) and H19 (103280) genes on 11p15.5 are monoallelically expressed as the result of genomic imprinting and show altered expression in Wilms tumors (WT1; 607102). To map regional imprinting, Tsang et al. (1995) sought to isolate additional genes close to IGF2/H19 and to characterize their allelic expression patterns. They reported a novel gene, which they provisionally named L23MRP (for L23 mitochondrial-related protein), which is oriented 'tail-to-tail' with H19 and is transcribed to within 40-kb of the last H19 exon. L23MRP is expressed biallelically in many mid-fetal and adult human tissues. The gene is also expressed at normal levels in Wilms tumors, which have lost expression of H19 either via loss of the maternal chromosome 11p15.5 or via an epigenetic pathway involving site-specific DNA hypermethylation. These data indicated that, at least in postembryonic stages, L23MRP is functionally insulated from the IGF2/H19 imprinted domain.
Tsang et al. (1995) identified the L23MRP gene on chromosome 11p15.5.
Tsang, P., Gilles, F., Yuan, L., Kuo, Y.-H., Lupu, F., Samara, G., Moosikasuwan, J., Goye, A., Zelenetz, A. D., Selleri, L., Tycko, B. A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues. Hum. Molec. Genet. 4: 1499-1507, 1995. [PubMed: 8541832] [Full Text: https://doi.org/10.1093/hmg/4.9.1499]