Alternative titles; symbols
HGNC Approved Gene Symbol: TRIM26
Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,184,455-30,213,406 (from NCBI)
Chu et al. (1995) performed positional cloning of short fragment cDNA sequences from the class I region of the human major histocompatibility complex (MHC) using a hybridization selection approach. They isolated full-length cDNA clones and partial genomic clones encoding a protein with 2 domains rich in cysteine and histidine similar to those characteristic of metal-dependent DNA-binding proteins. The predicted protein also contains a domain thought to form a coiled-coil, possibly to promote dimerization. A third feature of the predicted protein is a polyglutamic acid region near the carboxyl terminus. Because of these properties, Chu et al. (1995) named the gene product acid-finger protein, AFP (a designation used originally for alpha-fetoprotein (AFP; 104150)). Although the biologic role of AFP was unknown, one potential function was binding of nucleic acids. The gene was expressed in multiple tissues and conserved among mammals. In particular, the mouse and human coding regions were highly conserved.
Chu et al. (1995) identified the AFP gene within the MHC on chromosome 6. It appeared that multiple AFP-like genes existed in this region of the MHC.
Chu, T. W., Capossela, A., Coleman, R., Goei, V. L., Nallur, G., Gruen, J. R. Cloning of a new 'finger' protein gene (ZNF173) within the class I region of the human MHC. Genomics 29: 229-239, 1995. [PubMed: 8530076] [Full Text: https://doi.org/10.1006/geno.1995.1236]