Alternative titles; symbols
HGNC Approved Gene Symbol: TCF19
Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,158,589-31,164,215 (from NCBI)
Ku et al. (1991) cloned a growth-regulated cDNA by differential screening of a mouse 3T3 cell line library to identify transcripts induced by serum stimulation. Transcripts of the gene, designated SC1, were detectable beginning at about 8 hours after stimulation. The mouse cDNA was used to clone the human SC1 cDNA. The 2.6-kb cDNA encoded a deduced 359-amino acid polypeptide with features characteristic of transactivating factors. The gene was mapped by in situ hybridization to chromosome 6p21-p22. The bacterially expressed protein had the predicted size of 39 kD.
Krishnan et al. (1995) mapped TCF19 with POU5F1 (164177) to a 0.2-Mb region between HLA-C (142840) and the so-called S gene (602593) at 6p21.3. POU5F1 and TCF19 are about 130 kb telomeric of HLAC and about 600 bp from each other.
Krishnan, B. R., Jamry, I., Chaplin, D. D. Feature mapping of the HLA class I region: localization of the POU5F1 and TCF19 genes. Genomics 30: 53-58, 1995. [PubMed: 8595903] [Full Text: https://doi.org/10.1006/geno.1995.0008]
Ku, D.-H., Chang, C.., Koniecki, J., Cannizzaro, L. A., Boghosian-Sell, L., Alder, H., Baserga, R. A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor. Cell Growth Differ. 2: 179-186, 1991. [PubMed: 1868030]