HGNC Approved Gene Symbol: MOBP
Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:39,467,680-39,529,497 (from NCBI)
In the course of screening genes predominantly expressed in the spinal cord of the rat, Yamamoto et al. (1994) cloned a gene encoding a novel member of the CNS myelin-constituting proteins, which they designated myelin-associated oligodendrocytic basic protein (MOBP). MOBP is abundantly expressed specifically in oligodendrocytes at the mRNA level. Two isoforms were confirmed, one of which has proline-rich tandem repeats. The cDNA-derived primary structure predicted a small, soluble, basic protein. Immunoelectron microscopy showed that MOBP is expressed throughout compact myelin. All of these characteristics are similar to MBP (159430). Unlike MBP, MOBP is expressed exclusively in the CNS myelin.
By linkage analysis in interspecific crosses, McCallion et al. (1996) demonstrated that the Mobp gene maps to distal mouse chromosome 9 in a region that shows homology of synteny with human 3p22-p21.
The International Radiation Hybrid Mapping Consortium mapped the human MOBP gene to chromosome 3 (WI-13470).
McCallion, A. S., Guenet, J.-L., Montague, P., Griffiths, I. R., Savioz, A., Davies, R. W. The mouse gene (Mobp) encoding myelin-associated oligodendrocytic basic protein maps to distal chromosome 9. Mammalian Genome 7: 847-849, 1996. [PubMed: 8875894] [Full Text: https://doi.org/10.1007/s003359900248]
Yamamoto, Y., Mizuno, R., Nishimura, T., Ogawa, Y., Yoshikawa, H., Fujimura, H., Adachi, E., Kishimoto, T., Yanagihara, T., Sakoda, S. Cloning and expression of myelin-associated oligodendrocytic basic protein: a novel basic protein constituting the central nervous system myelin. J. Biol. Chem. 269: 31725-31730, 1994. [PubMed: 7989345]