Alternative titles; symbols
HGNC Approved Gene Symbol: DAP
Cytogenetic location: 5p15.2 Genomic coordinates (GRCh38): 5:10,679,230-10,761,234 (from NCBI)
Death-associated protein (DAP) and death-associated protein kinase (DAPK1; 600831) are positive mediators of the programmed cell death induced by gamma-interferon (IFNG; 147570). The inactivation of these genes by antisense RNA expression reduced the susceptibility of HeLa cells to IFNG-induced apoptosis. DAP is expressed as a single 2.4-kb mRNA that codes for a basic proline-rich 15-kD protein. DAPK1 is transcribed into a single 6.3-kb mRNA encoded for a structurally unique 160-kD calmodulin (114180)-dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites (Deiss et al., 1995).
By analysis of rodent-human somatic cell hybrids, Feinstein et al. (1995) mapped the DAP gene to chromosome 5p15.2. (The title of the article by Feinstein et al. (1995) erroneously stated that the DAP gene had been mapped to chromosome 5p12.2.)
Deiss, L. P., Feinstein, E., Berissi, H., Cohen, O., Kimchi, A. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev. 9: 15-30, 1995. [PubMed: 7828849] [Full Text: https://doi.org/10.1101/gad.9.1.15]
Feinstein, E., Druck, T., Kastury, K., Berissi, H., Goodart, S. A., Overhauser, J., Kimchi, A., Huebner, K. Assignment of DAP1 and DAPK: genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively. Genomics 29: 305-307, 1995. [PubMed: 8530096] [Full Text: https://doi.org/10.1006/geno.1995.1255]