HGNC Approved Gene Symbol: RNASE4
Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,684,560-20,701,216 (from NCBI)
Rosenberg and Dyer (1995) stated that, at the time of their report, this ribonuclease was the fifth human member of the mammalian ribonuclease gene family to be discovered; other members include pancreatic ribonuclease (180440), eosinophil-derived neurotoxin (RNS2; 131410), eosinophil cationic protein (RNS3; 131398), and angiogenin (105850). Rosenberg and Dyer (1995) referred to the protein as ribonuclease 4 (RNase4). By Northern analysis, mRNA for the gene was detected in human pancreas, lung, skeletal muscle, heart, kidney, and placenta, but not brain; liver represented the most abundant source. The authors noted that the mRNA encoding this ribonuclease is approximately 2 kb in length, or approximately twice as long as the mRNAs encoding other members of this gene family. They also detected a larger (approximately 2.4 kb), second transcript in hepatic, pancreatic, and renal tissues.
By PCR analysis of human/hamster somatic cell hybrids, Rosenberg and Dyer (1995) determined that the gene encoding the RNASE4 protein resides in a single exon found on human chromosome 14. RNS2 and RNS3 also reside on chromosome 14.
Ribonuclease L (RNASEL; 180435), which maps to chromosome 1q25, has also been referred to as RNS4.
Rosenberg, H. F., Dyer, K. D. Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues. Nucleic Acids Res. 23: 4290-4295, 1995. [PubMed: 7501448] [Full Text: https://doi.org/10.1093/nar/23.21.4290]