Entry - 601079 - ZRSR2 PSEUDOGENE 1; ZRSR2P1 - OMIM

 
 
601079

ZRSR2 PSEUDOGENE 1; ZRSR2P1


Alternative titles; symbols

ZINC FINGER-, CCCH DOMAIN-, AND RNA-BINDING MOTIF-CONTAINING SERINE/ARGININE-RICH PROTEIN 1; ZRSR1
U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR, SMALL SUBUNIT 1; U2AF1RS1


HGNC Approved Gene Symbol: ZRSR2P1

Cytogenetic location: 5q22     Genomic coordinates (GRCh38): 5:110,200,001-115,900,000


TEXT

▼ Cloning and Expression

Hatada et al. (1991) isolated the imprinted mouse gene U2af1rs1 by restriction landmark genomic scanning. This gene is related to the human ribonucleoprotein auxiliary factor (191317) required for RNA splicing.

Kitagawa et al. (1995) isolated 3 human homologs of mouse U2af1rs1. The predicted 479-amino acid U2AF1RS1 protein is 92.1% identical to U2AF1RS2 (300028) and 78.8% identical to the mouse U2af1rs1 protein. In their Table 1, Kitagawa et al. (1995) presented DNA sequence analysis data which revealed higher similarity between the human U2AF1RS1 and U2AF1RS2 genes (94.6%) than that observed between the 2 mouse homologs (76.7%). See also 601080, the human locus they designated U2AF1RS3.


▼ Mapping

Kitagawa et al. (1995) mapped the ZRSR1 gene to chromosome 5q22 by fluorescence in situ hybridization.


▼ REFERENCES

  1. Hatada, I., Hayashizaki, Y., Hirotsune, S., Komatsubara, H., Mukai, T. A genomic scanning method for higher organisms using restriction sites as landmarks. Proc. Nat. Acad. Sci. 88: 9523-9527, 1991. [PubMed: 1946366, related citations] [Full Text]

  2. Kitagawa, K., Wang, X., Hatada, I., Yamaoka, T., Nojima, H., Inazawa, H., Abe, T., Mitsuya, K., Oshimura, M., Murata, A., Monden, M., Mukai, T. Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1. Genomics 30: 257-263, 1995. [PubMed: 8586425, related citations] [Full Text]


Creation Date:
Alan F. Scott : 2/20/1996
Edit History:
mgross : 10/28/2019
alopez : 11/29/2010
alopez : 11/29/2010
dkim : 12/11/1998
mark : 5/28/1996
terry : 5/22/1996
terry : 5/20/1996
terry : 3/27/1996
mark : 2/20/1996

601079

ZRSR2 PSEUDOGENE 1; ZRSR2P1


Alternative titles; symbols

ZINC FINGER-, CCCH DOMAIN-, AND RNA-BINDING MOTIF-CONTAINING SERINE/ARGININE-RICH PROTEIN 1; ZRSR1
U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR, SMALL SUBUNIT 1; U2AF1RS1


HGNC Approved Gene Symbol: ZRSR2P1

Cytogenetic location: 5q22     Genomic coordinates (GRCh38): 5:110,200,001-115,900,000


TEXT

Cloning and Expression

Hatada et al. (1991) isolated the imprinted mouse gene U2af1rs1 by restriction landmark genomic scanning. This gene is related to the human ribonucleoprotein auxiliary factor (191317) required for RNA splicing.

Kitagawa et al. (1995) isolated 3 human homologs of mouse U2af1rs1. The predicted 479-amino acid U2AF1RS1 protein is 92.1% identical to U2AF1RS2 (300028) and 78.8% identical to the mouse U2af1rs1 protein. In their Table 1, Kitagawa et al. (1995) presented DNA sequence analysis data which revealed higher similarity between the human U2AF1RS1 and U2AF1RS2 genes (94.6%) than that observed between the 2 mouse homologs (76.7%). See also 601080, the human locus they designated U2AF1RS3.


Mapping

Kitagawa et al. (1995) mapped the ZRSR1 gene to chromosome 5q22 by fluorescence in situ hybridization.


REFERENCES

  1. Hatada, I., Hayashizaki, Y., Hirotsune, S., Komatsubara, H., Mukai, T. A genomic scanning method for higher organisms using restriction sites as landmarks. Proc. Nat. Acad. Sci. 88: 9523-9527, 1991. [PubMed: 1946366] [Full Text: https://doi.org/10.1073/pnas.88.21.9523]

  2. Kitagawa, K., Wang, X., Hatada, I., Yamaoka, T., Nojima, H., Inazawa, H., Abe, T., Mitsuya, K., Oshimura, M., Murata, A., Monden, M., Mukai, T. Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1. Genomics 30: 257-263, 1995. [PubMed: 8586425] [Full Text: https://doi.org/10.1006/geno.1995.9879]


Creation Date:
Alan F. Scott : 2/20/1996

Edit History:
mgross : 10/28/2019
alopez : 11/29/2010
alopez : 11/29/2010
dkim : 12/11/1998
mark : 5/28/1996
terry : 5/22/1996
terry : 5/20/1996
terry : 3/27/1996
mark : 2/20/1996



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 8, 2024