Alternative titles; symbols
HGNC Approved Gene Symbol: CRIP2
Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:105,472,945-105,480,170 (from NCBI)
By low stringency screening of a human small intestine cDNA library with a rat cysteine-rich intestinal protein (CRIP1; 123875) cDNA, Karim et al. (1996) isolated a cDNA encoding CRIP2, which they called ESP1/CRP2. The cDNA predicts a 208-amino acid protein containing 2 LIM domains. CRIP2 shares 93% amino acid sequence identity with its rat homolog, called Esp1 or Crp2. Northern blot analysis showed widespread tissue expression of the 1.3-kb CRIP2 mRNA, with the highest level of expression found in heart. In testis, a second 1.7-kb mRNA was also detected.
Tsui et al. (1996) cloned a human heart cDNA encoding CRIP2, which they called CRP2. CRIP2 is 38% and 35% identical to the CSRP1 (123876) and CSRP3 (600824) proteins, respectively.
Tsui et al. (1996) mapped the CRIP2 gene to 14q32 using fluorescence in situ hybridization (FISH). By somatic cell hybrid analysis and FISH, Karim et al. (1996) mapped the CRIP2 gene to 14q32.3.
Karim, M. A., Ohta, K., Egashira, M., Jinno, Y., Niikawa, N., Matsuda, I., Indo, Y. Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3. Genomics 31: 167-176, 1996. [PubMed: 8824798] [Full Text: https://doi.org/10.1006/geno.1996.0028]
Tsui, S. K. W., Chan, P. P. K., Cheuk, C. W., Liew, C. C., Waye, M. M. Y., Fung, K. P., Lee, C. Y. A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation. Biochem. Molec. Biol. Int. 39: 747-754, 1996. [PubMed: 8843343] [Full Text: https://doi.org/10.1080/15216549600201831]