Alternative titles; symbols
Cytogenetic location: 10pter-q11 Genomic coordinates (GRCh38): 10:1-51,100,000
| Location | Phenotype |
Phenotype MIM number |
Inheritance |
Phenotype mapping key |
|---|---|---|---|---|
| 10pter-q11 | Prostate adenocarcinoma | 601188 | 2 |
Prostate cancer (176807) is the second leading cause of male cancer deaths in the United States. Sanchez et al. (1996) noted that, while prostate secretory epithelial cells and androgen-dependent prostate carcinomas undergo apoptosis in response to androgen deprivation, most prostate carcinomas become androgen independent and refractory to further therapeutic manipulations during disease progression. Sanchez et al. (1996) undertook to define the genetic events that trigger apoptosis in the prostate. They reported the functional definition of a novel genetic locus within 10pter-q11 that mediates both in vivo tumor suppression and in vitro apoptosis in prostatic adenocarcinoma cells. A defined fragment of human chromosome 10 was transferred via microcell fusion into a prostate adenocarcinoma cell line. Microcell hybrids containing only the region 10pter-q11 were suppressed for tumorigenicity following injection of microcell hybrids into nude mice. Furthermore, the complemented hybrids underwent programmed cell death in vitro via a mechanism that does not require nuclear localization of p53 (191170). Sanchez et al. (1996) concluded that a novel genetic locus, designated prostate adenocarcinoma 1 (PAC1) by them, is involved in tumor suppression of human prostate carcinoma and that the cell death pathway might be functionally restored in prostatic adenocarcinoma with therapeutic benefit.
Sanchez, Y., Lovell, M., Marin, M. C., Wong, P. E., Wolf-Ledbetter, M. E., McDonnell, T. J., Killary, A. M. Tumor suppression and apoptosis of human prostate carcinoma mediated by a genetic locus within human chromosome 10pter-q11. Proc. Nat. Acad. Sci. 93: 2551-2556, 1996. [PubMed: 8637912] [Full Text: https://doi.org/10.1073/pnas.93.6.2551]