Alternative titles; symbols
DO: 0110750;
Cytogenetic location: 14q24.3-q31 Genomic coordinates (GRCh38): 14:73,300,001-89,300,000
| Location | Phenotype |
Phenotype MIM number |
Inheritance |
Phenotype mapping key |
|---|---|---|---|---|
| 14q24.3-q31 | {Diabetes mellitus, insulin-dependent, 11} | 601208 | 2 |
Field et al. (1996) used the symbol IDDM11 for a susceptibility locus for insulin-dependent diabetes mellitus located on 14q24.3-q31. The locus was identified by demonstration of significant linkage to microsatellite D14S67, using both maximum likelihood methods and affected sib pair methods. They claimed that this represented the strongest reported evidence for linkage to any IDDM locus outside the HLA region. The subset of families in which affected children did not show increased sharing of HLA genes provided most of the support for D14S67 linkage. There was significant linkage heterogeneity between the HLA-defined subsets of families, suggesting to Field et al. (1996) that IDDM11 may be an important susceptibility locus in families lacking strong HLA region predisposition.
Corder et al. (2001) used 'grade-of-membership' (GoM) in sib pair linkage analysis to map the IDDM11 locus to 14q24.3.
Corder, E. H., Woodbury, M. A., Manton, K. G., Field, L. L. Grade-of-membership sibpair linkage analysis maps IDDM11 to chromosome 14q24.3-q31. Ann. Hum. Genet. 65: 387-394, 2001. [PubMed: 11592928] [Full Text: https://doi.org/10.1017/S0003480001008685]
Field, L. L., Tobias, R., Thomson, G., Plon, S. Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31. Genomics 33: 1-8, 1996. [PubMed: 8617492] [Full Text: https://doi.org/10.1006/geno.1996.0153]