Alternative titles; symbols
HGNC Approved Gene Symbol: SULT1A2
Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,591,943-28,597,050 (from NCBI)
Her et al. (1996) and Dooley and Huang (1996) reported the sequence of the SULT1A2 gene.
Sulfonation is an important pathway in the biotransformation of many drugs, xenobiotics, neurotransmitters, and steroid hormones. The thermostable form of phenol sulfotransferase preferentially catalyzes the sulfonation of 'simple' planar phenols. The phenol sulfotransferase STP1 (171150) maps to chromosome 16. Her et al. (1996) determined the structure and chromosomal localization of the gene encoding a second phenol sulfotransferase, STP2. The gene spans approximately 5.1 kb and contains 9 exons that range in length from 74 to 347 bp. Exons 1A and 1B as well as the 5-prime portion of exon 2 and the 3-prime portion of exon 8 are noncoding. The locations of most STP2 exon/intron splice junctions are identical to those of a gene for the thermolabile form of PST in humans, STM (600641), which maps to 16p close to the location of the thermostable STP1.
Dooley and Huang (1996) determined that 7 coding exons are conserved among the human STP1, STP2, and STM (600641) genes. The initiator methionine is found on exon 2. All 3 genes colocalized on a single cosmid from chromosome 16p12.1-p11.2 and have a high degree of sequence homology, suggesting that these 3 genes arose by gene duplication. Dooley and Huang (1996) stated that the previously identified PST gene sequences HAST4, HAST4v, and ST1A2 are isolates of the STP2 gene.
Her et al. (1996) mapped STP2 to human chromosome 16 by PCR with DNA from human/rodent somatic cell hybrids.
Dooley, T. P., Huang, Z. Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16. Biochem. Biophys. Res. Commun. 228: 134-140, 1996. [PubMed: 8912648] [Full Text: https://doi.org/10.1006/bbrc.1996.1628]
Her, C., Raftogianis, R., Weinshilboum, R. M. Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization. Genomics 33: 409-420, 1996. [PubMed: 8661000] [Full Text: https://doi.org/10.1006/geno.1996.0216]