Alternative titles; symbols
HGNC Approved Gene Symbol: TBCB
Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:36,114,967-36,125,941 (from NCBI)
The cytoskeleton is composed of 3 structural elements: actin filaments, microtubules, and intermediate filaments. Cytoskeletal activity is modulated by many cytoskeleton-associated proteins (CAPs). One group of CAPs is characterized by a highly conserved glycine motif, the CAP-GLY domain, which may contribute to its association with microtubules. Members of the group of CAPs include dynactin (601143), the dynein-associated protein. Watanabe et al. (1996) isolated a novel member of this family, which they called CKAPI (for cytoskeleton-associated protein I, glycine motif). The cDNA was isolated from a human fetal-brain cDNA library and found to contain an open reading frame of 579 nucleotides encoding a 193-amino acid polypeptide. Three transcripts of different sizes were expressed in all tissues examined.
By fluorescence in situ hybridization, Watanabe et al. (1996) assigned the gene to 19q13.11-q13.12.
Watanabe, T. K., Shimizu, F., Nagata, M., Kawai, A., Fujiwara, T., Nakamura, Y., Takahashi, E., Hirai, Y. Cloning, expression, and mapping of CKAP1, which encodes a putative cytoskeleton-associated protein containing a CAP-GLY domain. Cytogenet. Cell Genet. 72: 208-211, 1996. [PubMed: 8978778] [Full Text: https://doi.org/10.1159/000134191]