Alternative titles; symbols
HGNC Approved Gene Symbol: LY6E
Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,018,529-143,022,409 (from NCBI)
By differential display-PCR, Mao et al. (1996) isolated and characterized a gene, which they designated RIGE, whose expression is upregulated by all-trans-retinoic acid (ATRA). The deduced amino acid sequence predicts a cell surface protein containing 20 amino acids at the N-terminal end corresponding to a signal peptide and an extracellular sequence containing 111 amino acids. The RIGE encoded protein shares some homology with CD59 (107271) and with a number of growth factor receptors. It shares high sequence homology with the murine LY6 multigene family, whose members are small cysteine-rich proteins differentially expressed in several hematopoietic cell lines and with apparent function in signal transduction. Mao et al. (1996) suggested that RIGE is the closest human homolog of the LY6 family. They noted that expression of RIGE is not restricted to myeloid differentiation, because it is also present in thymocytes and in a number of other tissues at different levels. By Northern blot analysis, Shan et al. (1998) found the highest expression of RIGE in liver, kidney, and ovary in addition to peripheral blood leukocytes.
Mao et al. (1996) found that the RIGE gene is 4.0 kb long and consists of 4 exons and 3 introns, of which only the last 3 exons, separated by short introns, are coding.
By fluorescence in situ hybridization, Mao et al. (1996) mapped the RIGE gene to 8q24.
Mao, M., Yu, M., Tong, J.-H., Ye, J., Zhu, J., Huang, Q.-H., Fu, G., Yu, L., Zhao, S.-Y., Waxman, S., Lanotte, M., Wang, Z.-Y., Tan, J.-Z., Chan, S.-J., Chen, Z. RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell. Proc. Nat. Acad. Sci. 93: 5910-5914, 1996. [PubMed: 8650192] [Full Text: https://doi.org/10.1073/pnas.93.12.5910]
Shan, X., Bourdeau, A., Rhoton, A., Wells, D. E., Cohen, E. H., Landgraf, B. E., Palfree, R. G. E. Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1. J. Immun. 160: 197-208, 1998. [PubMed: 9551972]