Alternative titles; symbols
HGNC Approved Gene Symbol: FCGR1BP
Cytogenetic location: 1p11.2 Genomic coordinates (GRCh38): 1:121,087,345-121,097,161 (from NCBI)
The high-affinity receptor for immunoglobulin G, Fc-gamma-RI (FCGR1), is encoded by a family of 3 genes that share over 98% DNA sequence homology. Using both fluorescence in situ hybridization analysis of human cells and Southern analysis of cell lines containing 1p and 1q, Maresco et al. (1996) demonstrated that all 3 genes flank the centromere of chromosome 1 at bands 1p12 and 1q21. FCGR1B was found at 1p12, whereas both FCGR1A (146760) and FCGR1C (601503) were localized to 1q21. This placed the FCGR1 gene family within a large pericentric linkage group that is conserved between humans and mice. Maresco et al. (1996) hypothesized that the 3 FCGR1 genes were separated by a pericentric inversion, known to have occurred on human chromosome 1, which relocated FCGR1A and FCGR1C to the long arm and left FCGR1B positioned on the short arm.
Maresco, D. L., Chang, E., Theil, K. S., Francke, U., Anderson, C. L. The three genes of the human FCGR1 gene family encoding Fc-gamma-RI flank the centromere of chromosome 1 at 1p12 and 1q21. Cytogenet. Cell Genet. 73: 157-163, 1996. [PubMed: 8697799] [Full Text: https://doi.org/10.1159/000134330]