Alternative titles; symbols
HGNC Approved Gene Symbol: EPYC
Cytogenetic location: 12q21.33 Genomic coordinates (GRCh38): 12:90,963,682-91,004,972 (from NCBI)
PG-Lb is a small dermatan sulfate proteoglycan that was originally isolated from chick embryo cartilage by Shinomura et al. (1983). In the developing limb, chick PG-Lb appears to be expressed exclusively in the zone of flattened chondrocytes.
Deere et al. (1996) cloned and sequenced the human homolog of chick PG-Lb from 2 human chondrocyte cDNA libraries and a human chondrocyte RNA sample. They named the human homolog dermatan sulfate proteoglycan-3 (DSPG3) and stated that it was the third member of the small dermatan sulfate proteoglycan family to be identified and characterized, the first 2 being biglycan (301870) and decorin (125255). The 1,515-bp DSPG3 gene encodes a predicted 322-amino acid protein. The protein contains 3 potential glycosaminoglycan attachment sites, 2 N-glycosylation sites, a polyglutamic acid stretch, and 6 cysteines. By Northern analysis, Deere et al. (1996) demonstrated that DSPG3 is expressed in cartilage, as well as ligament and placental tissues.
By PCR analysis of DNA from a somatic cell hybrid panel followed by fluorescence in situ hybridization, Deere et al. (1996) mapped the DSPG3 gene to 12q21. They confirmed the localization by PCR mapping of DSPG3 to a YAC contig map of chromosome 12.
Deere, M., Johnson, J., Garza, S., Harrison, W. R., Yoon, S.-J., Elder, F. F. B., Kucherlapati, R., Hook, M., Hecht, J. T. Characterization of human DSPG3, a small dermatan sulfate proteoglycan. Genomics 38: 399-404, 1996. [PubMed: 8975717] [Full Text: https://doi.org/10.1006/geno.1996.0643]
Shinomura, T., Kimata, K., Oike, Y., Noro, A., Hirose, N., Tanabe, K., Suzuki, S. The occurrence of three different proteoglycan species in chick embryo cartilage: isolation and characterization of a second proteoglycan (PG-Lb) and its precursor form. J. Biol. Chem. 258: 9314-9322, 1983. [PubMed: 6874690]