Alternative titles; symbols
HGNC Approved Gene Symbol: SP2
Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,896,236-47,931,731 (from NCBI)
Kingsley and Winoto (1992) investigated transcription factors which bind to the GT box, a T-cell transcriptional regulatory element which is similar to the GC box, the classical binding site for SP1 (189906). Gel shift assays showed that SP1 and 2 additional DNA-protein complexes bound to the GT box. The authors then cloned 2 novel GT box-binding cDNAs from a human cDNA expression library. They termed these new transcription factors SP2 and SP3 (601804). These genes encode proteins with several transactivation domains and a zinc finger DNA-binding domain with homology to SP1. Kingsley and Winoto (1992) reported that the SP2 cDNA encodes a 495-amino acid polypeptide which is 72% identical to SP1 within the zinc finger domain. However, they noted that SP2, unlike SP3, has limited homology to SP1. Northern blot analysis shows that the SP2 gene produces a 3.2-kb message expressed in several cell lines. When expressed in vitro, SP2 binds the GT box weakly but does not bind the GC box.
Suske et al. (2005) stated that the human SP2 gene maps to chromosome 17q21.32, and the mouse Sp2 gene to chromosome 11D.
Kingsley, C, Winoto, A. Cloning of GT box-binding proteins: a novel SP1 multigene family regulating T-cell receptor gene expression. Molec. Cell Biol. 12: 4251-4261, 1992. [PubMed: 1341900] [Full Text: https://doi.org/10.1128/mcb.12.10.4251-4261.1992]
Suske, G., Bruford, E., Philipsen, S. Mammalian SP/KLF transcription factors: bring in the family. Genomics 85: 551-556, 2005. [PubMed: 15820306] [Full Text: https://doi.org/10.1016/j.ygeno.2005.01.005]