Alternative titles; symbols
Naz et al. (1984, 1986) reported a monoclonal antibody that inhibits fertilization in mice and humans and studied the antigen it recognizes. The antigen, called fertilization antigen-1 (FA1) by them, is a glycoprotein of 23 kD in the monomeric state that has a ligand activity for ZP3A (182889) of oocyte zona pellucida and causes a reduction in fertility of actively immunized female rabbits. Zhu and Naz (1997) cloned and sequenced a cDNA encoding FA1 from murine testis, demonstrated its testis-specific expression, and showed immunocontraceptive effects of the recombinant protein.
Scott (2007) stated that there is no evidence for the existence of this gene in humans. He found that the protein sequence in the paper of Naz and Zhu (2002) does not match anything human (build 35.1).
Naz, R. K., Alexander, N. J., Isahakia, M., Hamilton, M. S. Monoclonal antibody to a human germ cell membrane glycoprotein that inhibits fertilization. Science 225: 342-344, 1984. [PubMed: 6539947] [Full Text: https://doi.org/10.1126/science.6539947]
Naz, R. K., Phillips, T. M., Rosenblum, B. B. Characterization of the fertilization antigen 1 for the development of a contraceptive vaccine. Proc. Nat. Acad. Sci. 83: 5713-5717, 1986. [PubMed: 3461457] [Full Text: https://doi.org/10.1073/pnas.83.15.5713]
Naz, R. K., Zhu, X. Molecular cloning and sequencing of cDNA encoding for human FA-1 antigen. Molec. Reprod. Dev. 63: 256-268, 2002. [PubMed: 12203836] [Full Text: https://doi.org/10.1002/mrd.90010]
Scott, A. F. Personal Communication. Baltimore, Md. 2/8/2007.
Zhu, X., Naz, R. K. Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects. Proc. Nat. Acad. Sci. 94: 4704-4709, 1997. [PubMed: 9114055] [Full Text: https://doi.org/10.1073/pnas.94.9.4704]