Alternative titles; symbols
HGNC Approved Gene Symbol: SRPK1
Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,832,966-35,921,098 (from NCBI)
Small nuclear ribonucleoprotein particles (snRNPs) and non-snRNP splicing factors containing a serine/arginine-rich domain (SR proteins) concentrate in 'speckles' in the nucleus of interphase cells. These nuclear 'speckles' act as storage sites for splicing factors. Gui et al. (1994) identified a kinase, designated SRPK1 (SR protein-specific kinase-1), based on its ability to phosphorylate SC35 (SFRS2; 600813). The SRPK1 gene was cloned; it encodes a protein of 655 amino acids. SRPK1 is similar to a hypothetical C. elegans kinase, CEHK, and to the fission yeast kinase Dsk1. The association of phosphorylation of SR proteins in vivo with SRPK1 activity in the extracts, together with the fact that SRPK1 was the only major kinase for SR proteins obtained during purification, strongly suggests that SRPK1 is responsible for phosphorylation of SR proteins during the cell cycle in vivo.
Using a somatic cell hybrid mapping panel and FISH, Wang et al. (1999) mapped the SRPK1 gene to chromosome 6p21.3-p21.2. They mapped the mouse Srpk1 gene to chromosome 17.
Gui, J.-F., Lane, W. S., Fu, X.-D. A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature 369: 678-682, 1994. [PubMed: 8208298] [Full Text: https://doi.org/10.1038/369678a0]
Wang, H.-Y., Arden, K. C., Bermingham, J. R., Jr., Viars, C. S., Lin, W., Boyer, A. D., Fu, X.-D. Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes. Genomics 57: 310-315, 1999. [PubMed: 10198174] [Full Text: https://doi.org/10.1006/geno.1999.5770]