Entry - *601981 - RIBONUCLEASE, RNase A FAMILY, 6; RNASE6 - OMIM

 
 
* 601981

RIBONUCLEASE, RNase A FAMILY, 6; RNASE6


Alternative titles; symbols

RNase k6


HGNC Approved Gene Symbol: RNASE6

Cytogenetic location: 14q11.2     Genomic coordinates (GRCh38): 14:20,781,070-20,782,467 (from NCBI)


TEXT

▼ Cloning and Expression

Rosenberg and Dyer (1996) identified ribonuclease-6, which they referred to as RNase k6, as an unexpected result of their efforts to trace the evolutionary history of the ribonuclease gene family. RNASE6 encodes a 150-amino acid polypeptide most closely related to ribonuclease-2 (RNASE2; 131410); these 2 proteins share 47% amino acid sequence identity. RNASE6 mRNA was detected in all human tissues tested, with lung representing the most abundant source.


▼ Mapping

Rosenberg and Dyer (1996) used a PCR-based technique to map the RNASE6 gene to chromosome 14.


▼ REFERENCES

  1. Rosenberg, H. F., Dyer, K. D. Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family. Nucleic Acids Res. 24: 3507-3513, 1996. [PubMed: 8836175, related citations] [Full Text]


Creation Date:
Lori M. Kelman : 9/8/1997
Edit History:
carol : 10/22/2014
carol : 4/14/2014
dholmes : 9/16/1997
dholmes : 9/8/1997
dholmes : 9/8/1997

* 601981

RIBONUCLEASE, RNase A FAMILY, 6; RNASE6


Alternative titles; symbols

RNase k6


HGNC Approved Gene Symbol: RNASE6

Cytogenetic location: 14q11.2     Genomic coordinates (GRCh38): 14:20,781,070-20,782,467 (from NCBI)


TEXT

Cloning and Expression

Rosenberg and Dyer (1996) identified ribonuclease-6, which they referred to as RNase k6, as an unexpected result of their efforts to trace the evolutionary history of the ribonuclease gene family. RNASE6 encodes a 150-amino acid polypeptide most closely related to ribonuclease-2 (RNASE2; 131410); these 2 proteins share 47% amino acid sequence identity. RNASE6 mRNA was detected in all human tissues tested, with lung representing the most abundant source.


Mapping

Rosenberg and Dyer (1996) used a PCR-based technique to map the RNASE6 gene to chromosome 14.


REFERENCES

  1. Rosenberg, H. F., Dyer, K. D. Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family. Nucleic Acids Res. 24: 3507-3513, 1996. [PubMed: 8836175] [Full Text: https://doi.org/10.1093/nar/24.18.3507]


Creation Date:
Lori M. Kelman : 9/8/1997

Edit History:
carol : 10/22/2014
carol : 4/14/2014
dholmes : 9/16/1997
dholmes : 9/8/1997
dholmes : 9/8/1997



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 15, 2024