HGNC Approved Gene Symbol: S100A13
Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,618,799-153,634,361 (from NCBI)
Wicki et al. (1996) reported the characterization of a human gene, S100A13, that encodes a calcium-binding protein belonging to the S100 protein family. S100 proteins are small EF-hand calcium-binding proteins of variable lengths and sequence identities. The predicted 98-amino acid S100A13 protein shows sequence homology to other S100 proteins between 50.5% (S100A5; 176991) and 59.3% (S100A12; 603112). Northern blot analysis showed high amounts of S100A13 mRNA in adult skeletal muscle, heart, kidney, ovary, spleen, small intestine, and pancreas and in fetal lung, heart, cochlea, liver, spleen, and parathyroid tumor cells. Moderate levels were detected in all other tissues examined, with the exception of placenta and leukocytes, which had very low or undetectable levels. Wicki et al. (1996) also cloned the mouse S100A13 gene, which encodes a 98-amino acid protein that displays 86.7% homology to human S100A13.
Wicki et al. (1996) mapped the S100A13 gene within a cluster of S100 genes on chromosome 1q21.
Wicki, R., Schafer, B. W., Erne, P., Heizmann, C. W. Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family. Biochem. Biophys. Res. Commun. 227: 594-599, 1996. [PubMed: 8878558] [Full Text: https://doi.org/10.1006/bbrc.1996.1551]