Entry - *602003 - LYMPHOID-RESTRICTED MEMBRANE PROTEIN; LRMP - OMIM

 
 
* 602003

LYMPHOID-RESTRICTED MEMBRANE PROTEIN; LRMP


Alternative titles; symbols

LYMPHOID PROTEIN OF ENDOPLASMIC RETICULUM
JAW1


HGNC Approved Gene Symbol: IRAG2

Cytogenetic location: 12p12.1     Genomic coordinates (GRCh38): 12:24,997,575-25,108,335 (from NCBI)


TEXT

▼ Description

LRMP is a lymphoid-restricted protein localized to the cytoplasmic face of the endoplasmic reticulum (ER), and is a member of a class of integral membrane proteins with a carboxyl-terminal membrane anchor (CTMA) without an amino-terminal signal sequence (summary by Behrens et al., 1996).


▼ Cloning and Expression

Behrens et al. (1994) performed a differential screen of a human B-lymphoma cDNA library to identify genes expressed preferentially in B-cell lines. The authors cloned and characterized a gene, which they called JAW1, that is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. JAW1 encodes a 539-amino acid polypeptide with a predicted molecular mass of 59.6 kD. The authors localized JAW1 to the cytoplasmic face of the endoplasmic reticulum (ER) by indirect immunofluorescence and confocal microscopy. The protein has a coiled-coil domain and a C-terminal membrane anchor with a conserved luminal tail region.


▼ Gene Function

Behrens et al. (1996) showed that the 71 C-terminal amino acids of the JAW1 protein, which contain a hydrophobic membrane-spanning region, are both necessary and sufficient for targeting a heterologous protein to the ER.


▼ Mapping

Gross (2014) mapped the LRMP gene to chromosome 12p12.1 based on an alignment of the LRMP sequence (GenBank BC126417) with the genomic sequence (GRCh37).

▼ REFERENCES

  1. Behrens, T. W., Jagadeesh, J., Scherle, P., Kearns, G., Yewdell, J., Staudt, L. M. Jaw1, a lymphoid-restricted membrane protein localized to the endoplasmic reticulum. J. Immun. 153: 682-690, 1994. [PubMed: 8021504, related citations]

  2. Behrens, T. W., Kearns, G. M., Rivard, J. J., Bernstein, H. D., Yewdell, J. W., Staudt, L. M. Carboxyl-terminal targeting and novel post-translational processing of JAW1, a lymphoid protein of the endoplasmic reticulum. J. Biol. Chem. 271: 23528-23534, 1996. [PubMed: 8798562, related citations] [Full Text]

  3. Gross, M. B. Personal Communication. Baltimore, Md. 4/15/2014.


Contributors:
Matthew B. Gross - updated : 04/15/2014
Creation Date:
Lori M. Kelman : 9/17/1997
Edit History:
alopez : 09/09/2022
mgross : 04/15/2014
carol : 4/14/2014
alopez : 3/15/2010
terry : 7/26/2006
dholmes : 11/12/1997
dholmes : 10/31/1997
dholmes : 10/2/1997
dholmes : 9/26/1997
dholmes : 9/18/1997

* 602003

LYMPHOID-RESTRICTED MEMBRANE PROTEIN; LRMP


Alternative titles; symbols

LYMPHOID PROTEIN OF ENDOPLASMIC RETICULUM
JAW1


HGNC Approved Gene Symbol: IRAG2

Cytogenetic location: 12p12.1     Genomic coordinates (GRCh38): 12:24,997,575-25,108,335 (from NCBI)


TEXT

Description

LRMP is a lymphoid-restricted protein localized to the cytoplasmic face of the endoplasmic reticulum (ER), and is a member of a class of integral membrane proteins with a carboxyl-terminal membrane anchor (CTMA) without an amino-terminal signal sequence (summary by Behrens et al., 1996).


Cloning and Expression

Behrens et al. (1994) performed a differential screen of a human B-lymphoma cDNA library to identify genes expressed preferentially in B-cell lines. The authors cloned and characterized a gene, which they called JAW1, that is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. JAW1 encodes a 539-amino acid polypeptide with a predicted molecular mass of 59.6 kD. The authors localized JAW1 to the cytoplasmic face of the endoplasmic reticulum (ER) by indirect immunofluorescence and confocal microscopy. The protein has a coiled-coil domain and a C-terminal membrane anchor with a conserved luminal tail region.


Gene Function

Behrens et al. (1996) showed that the 71 C-terminal amino acids of the JAW1 protein, which contain a hydrophobic membrane-spanning region, are both necessary and sufficient for targeting a heterologous protein to the ER.


Mapping

Gross (2014) mapped the LRMP gene to chromosome 12p12.1 based on an alignment of the LRMP sequence (GenBank BC126417) with the genomic sequence (GRCh37).

REFERENCES

  1. Behrens, T. W., Jagadeesh, J., Scherle, P., Kearns, G., Yewdell, J., Staudt, L. M. Jaw1, a lymphoid-restricted membrane protein localized to the endoplasmic reticulum. J. Immun. 153: 682-690, 1994. [PubMed: 8021504]

  2. Behrens, T. W., Kearns, G. M., Rivard, J. J., Bernstein, H. D., Yewdell, J. W., Staudt, L. M. Carboxyl-terminal targeting and novel post-translational processing of JAW1, a lymphoid protein of the endoplasmic reticulum. J. Biol. Chem. 271: 23528-23534, 1996. [PubMed: 8798562] [Full Text: https://doi.org/10.1074/jbc.271.38.23528]

  3. Gross, M. B. Personal Communication. Baltimore, Md. 4/15/2014.


Contributors:
Matthew B. Gross - updated : 04/15/2014

Creation Date:
Lori M. Kelman : 9/17/1997

Edit History:
alopez : 09/09/2022
mgross : 04/15/2014
carol : 4/14/2014
alopez : 3/15/2010
terry : 7/26/2006
dholmes : 11/12/1997
dholmes : 10/31/1997
dholmes : 10/2/1997
dholmes : 9/26/1997
dholmes : 9/18/1997



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 2, 2024