HGNC Approved Gene Symbol: SQLE
Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:124,998,505-125,022,283 (from NCBI)
Squalene epoxidase (EC 1.14.99.7) catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway (summary by Nagai et al., 1997).
By PCR analysis of a human/rodent somatic cell hybrid mapping panel, Nagai et al. (1997) demonstrated that the human SQLE gene maps to chromosome 8. The localization was refined by PCR analysis of a radiation hybrid panel. The results showed that human SQLE is most tightly linked to D8S508, which is reported to be located at 8q24.13-qter. The authors used fluorescence in situ hybridization to map SQLE to 8q24.1.
Nagai, M., Sakakibara, J., Wakui, K., Fukushima, Y., Igarashi, S., Tsuji, S., Arakawa, M., Ono, T. Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1. Genomics 44: 141-143, 1997. [PubMed: 9286711] [Full Text: https://doi.org/10.1006/geno.1997.4825]