HGNC Approved Gene Symbol: PIN1P1
Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:69,919,322-69,920,317 (from NCBI)
Campbell et al. (1997) identified a gene closely related to the gene encoding the essential nuclear peptidyl-prolyl cis/trans isomerase (PIN1; 601052) involved in the regulation of mitosis. The novel gene, designated PIN1L, is 89% identical at the nucleotide level to the PIN1 transcript, but contains a shift in the reading frame. It encodes a 100-amino acid variant protein consisting of 63 amino acids homologous (90% identical) to PIN1 and contains the entire WW domain, fused to a 37-amino acid tail.
By fluorescence in situ hybridization and somatic cell hybrid analysis, Campbell et al. (1997) mapped PIN1L to 1q31. They commented that the protein encoded by PIN1L may have some functional role or, alternatively, PIN1L may be a transcribed pseudogene.
Campbell, H. D., Webb, G. C., Fountain, S., Young, I. G. The human PIN1 peptidyl-prolyl cis/trans isomerase gene maps to human chromosome 19p13 and the closely related PIN1L gene to 1p31. Genomics 44: 157-162, 1997. [PubMed: 9299231] [Full Text: https://doi.org/10.1006/geno.1997.4854]