Alternative titles; symbols
HGNC Approved Gene Symbol: SERPINB10
Cytogenetic location: 18q22.1 Genomic coordinates (GRCh38): 18:63,907,958-63,936,111 (from NCBI)
The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-10 (PI10; SERPINB10) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997).
Riewald and Schleef (1995) cloned PI10, which they called bomapin, from a human bone marrow cDNA library. The deduced 397-amino acid protein has a calculated molecular mass of 45 kD and shares 48% sequence identity with PAI2 (173390) and elastase inhibitor (SERPINB1; 130135), A single 2.3-kb PI10 transcript was highly expressed in human bone marrow cells but was undetectable in all other analyzed human tissues.
Riewald and Schleef (1995) demonstrated that PI10 was able to form SDS-stable complexes with thrombin and trypsin. They suggested that PI10 may play a role in the regulation of protease activities during hematopoiesis.
Bartuski et al. (1997) found that the bomapin gene maps to 18q21.3 where at least 5 other ov-serpins map.
Bartuski, A. J., Kamachi, Y., Schick, C., Overhauser, J., Silverman, G. A. Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3. Genomics 43: 321-328, 1997. [PubMed: 9268635] [Full Text: https://doi.org/10.1006/geno.1997.4827]
Huber, R., Carrell, R. W. Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins. Biochemistry 28: 8951-8966, 1989. [PubMed: 2690952] [Full Text: https://doi.org/10.1021/bi00449a001]
Riewald, M., Schleef, R. R. Molecular cloning of bomapin (protease inhibitor 10), a novel human serpin that is expressed specifically in the bone marrow. J. Biol. Chem. 270: 26754-26757, 1995. [PubMed: 7592909] [Full Text: https://doi.org/10.1074/jbc.270.45.26754]