HGNC Approved Gene Symbol: ISLR
Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,173,710-74,176,871 (from NCBI)
From a subtracted retina cDNA library, constructed for the purpose of concentrating genes expressed more preferentially in retina than in brain, Nagasawa et al. (1997) isolated a cDNA for a novel human protein containing both a leucine-rich repeat (LRR) and an immunoglobulin (Ig)-like domain. This gene was referred to as ISLR for 'immunoglobulin superfamily containing LRR.' The predicted protein comprises 428 amino acids and contains a hydrophobic N-terminal 18-amino acid putative signal peptide. Despite the variety of their functions, all members of the Ig superfamily (see 147100) are involved in adhesion or binding to other proteins in solution or at the cell surface. Therefore it is possible that the ISLR protein may also interact with other proteins or cells. On Northern blot analysis, the authors found a 2.4-kb ISLR transcript in various human tissues, including retina, heart, skeletal muscle, prostate, ovary, small intestine, thyroid, adrenal cortex, testis, stomach, and spinal cord, as well as fetal lung and fetal kidney.
By fluorescence in situ hybridization, Nagasawa et al. (1997) mapped the ISLR gene to 15q23-q24.
Nagasawa, A., Kubota, R., Imamura, Y., Nagamine, K., Wang, Y., Asakawa, S., Kudoh, J., Minoshima, S., Mashima, Y., Oguchi, Y., Shimizu, N. Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR). Genomics 44: 273-279, 1997. [PubMed: 9325048] [Full Text: https://doi.org/10.1006/geno.1997.4889]