Entry - *602160 - TRANSCRIPTION FACTOR DP2; TFDP2 - OMIM

 
 
* 602160

TRANSCRIPTION FACTOR DP2; TFDP2


Alternative titles; symbols

E2F DIMERIZATION PARTNER 2; DP2


HGNC Approved Gene Symbol: TFDP2

Cytogenetic location: 3q23     Genomic coordinates (GRCh38): 3:141,944,428-142,149,544 (from NCBI)


TEXT

▼ Cloning and Expression

Zhang and Chellappan (1995) cloned an E2F dimerization partner, transcription factor DP2, from a human kidney cDNA library. The TFDP2 gene encodes a predicted 386-amino acid protein that is 68% identical to TFDP1 (189902). Northern blot analysis revealed 5 distinct transcript sizes ranging from 1.4 to 9.5 kb, with expression of at least one size observed in all cell lines tested.


▼ Gene Function

Zhang and Chellappan (1995) showed that TFDP2 is able to form a functional heterodimer with E2F1 (189971).


▼ Mapping

By fluorescence in situ hybridization, Zhang et al. (1997) mapped the TFDP2 gene to chromosome 3q23.


▼ REFERENCES

  1. Zhang, Y., Chellappan, S. P. Cloning and characterization of human DP2, a novel dimerization partner of E2F. Oncogene 10: 2085-2093, 1995. [PubMed: 7784053, related citations]

  2. Zhang, Y., Venkatraj, V. S., Fischer, S. G., Warburton, D., Chellappan, S. P. Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family. Genomics 39: 95-98, 1997. [PubMed: 9027491, related citations] [Full Text]


Creation Date:
Jennifer P. Macke : 12/10/1997
Edit History:
carol : 04/14/2014
carol : 10/11/1999
alopez : 12/17/1997
alopez : 12/11/1997
alopez : 12/10/1997

* 602160

TRANSCRIPTION FACTOR DP2; TFDP2


Alternative titles; symbols

E2F DIMERIZATION PARTNER 2; DP2


HGNC Approved Gene Symbol: TFDP2

Cytogenetic location: 3q23     Genomic coordinates (GRCh38): 3:141,944,428-142,149,544 (from NCBI)


TEXT

Cloning and Expression

Zhang and Chellappan (1995) cloned an E2F dimerization partner, transcription factor DP2, from a human kidney cDNA library. The TFDP2 gene encodes a predicted 386-amino acid protein that is 68% identical to TFDP1 (189902). Northern blot analysis revealed 5 distinct transcript sizes ranging from 1.4 to 9.5 kb, with expression of at least one size observed in all cell lines tested.


Gene Function

Zhang and Chellappan (1995) showed that TFDP2 is able to form a functional heterodimer with E2F1 (189971).


Mapping

By fluorescence in situ hybridization, Zhang et al. (1997) mapped the TFDP2 gene to chromosome 3q23.


REFERENCES

  1. Zhang, Y., Chellappan, S. P. Cloning and characterization of human DP2, a novel dimerization partner of E2F. Oncogene 10: 2085-2093, 1995. [PubMed: 7784053]

  2. Zhang, Y., Venkatraj, V. S., Fischer, S. G., Warburton, D., Chellappan, S. P. Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family. Genomics 39: 95-98, 1997. [PubMed: 9027491] [Full Text: https://doi.org/10.1006/geno.1996.4473]


Creation Date:
Jennifer P. Macke : 12/10/1997

Edit History:
carol : 04/14/2014
carol : 10/11/1999
alopez : 12/17/1997
alopez : 12/11/1997
alopez : 12/10/1997



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 19, 2024