Alternative titles; symbols
HGNC Approved Gene Symbol: ELF3
Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,010,587-202,017,183 (from NCBI)
Oettgen et al. (1997) isolated and characterized a novel member of the ETS transcription factor family (see 164720), which they called ESX (also known as ESS-E). This was the first ETS factor and one of only a few transcription factors known to be exclusively expressed in epithelial cells. ESX contains 2 putative DNA-binding domains: an ETS domain and an A/T hook domain.
By scanning mutagenesis, Kwon et al. (2003) identified a functional ESE1 site in the promoter region of MIP3-alpha (CCL20; 601960) expressed by Caco-2 human intestinal epithelial cells.
Oettgen et al. (1999) determined that the ELF3 gene contains 9 exons spanning approximately 5.8 kb of genomic DNA.
By fluorescence in situ hybridization (FISH), Oettgen et al. (1997) mapped the ESX gene to 1q32. By the same method, Tymms et al. (1997) refined the location to 1q32.2.
Kwon, J. H., Keates, S., Simeonidis, S., Grall, F., Libermann, T. A, Keates, A. C. ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3-alpha gene expression in Caco-2 human colonic epithelial cells. J. Biol. Chem. 278: 875-884, 2003. [PubMed: 12414801] [Full Text: https://doi.org/10.1074/jbc.M208241200]
Oettgen, P., Alani, R. M., Barcinski, M. A., Brown, L., Akbarali, Y., Boltax, J., Kunsch, C., Munger, K., Liebermann, T. A. Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the Ets family. Molec. Cell. Biol. 17: 4419-4433, 1997. [PubMed: 9234700] [Full Text: https://doi.org/10.1128/MCB.17.8.4419]
Oettgen, P., Barcinski, M., Boltax, J., Stolt, P., Akbarali, Y., Libermann, T. A. Genomic organization of the human ELF3 (ESE-1/ESX) gene, a member of the Ets transcription factor family, and identification of a functional promoter. Genomics 55: 358-362, 1999. [PubMed: 10049594] [Full Text: https://doi.org/10.1006/geno.1998.5681]
Oettgen, P., Carter, K. C., Augustus, M., Barcinski, M., Boltax, J., Kunsch, C., Libermann, T. A. The novel epithelial-specific Ets transcription factor gene ESX maps to human chromosome 1q32.1. Genomics 45: 456-457, 1997. [PubMed: 9463090] [Full Text: https://doi.org/10.1006/geno.1997.4974]
Tymms, M. J., Ng, A. Y. N., Thomas, R. S., Schutte, B. C., Zhou, J., Eyre, H. J., Sutherland, G. R., Seth, A., Rosenberg, M., Papas, T., Debouck, C., Kola, I. A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer. Oncogene 15: 2449-2462, 1997. [PubMed: 9395241] [Full Text: https://doi.org/10.1038/sj.onc.1201427]