Alternative titles; symbols
HGNC Approved Gene Symbol: CD180
Cytogenetic location: 5q12.3 Genomic coordinates (GRCh38): 5:67,179,613-67,196,799 (from NCBI)
RP105 is a mouse B-cell surface molecule that transmits a growth-promoting signal and is implicated in the life/death decision of B cells. Miura et al. (1996) cloned the human homolog of RP105 using the mouse homolog as probe. The cDNA encodes a 661-amino acid polypeptide containing a putative signal sequence, a single transmembrane region, and leucine-rich repeats in the extracellular domain. Northern blotting of human leukocyte cell lines showed that RP105 was expressed in some B cells and monocytes, but not in T cells.
By Western blot and flow cytometry analyses, Miura et al. (1998) determined that surface expression of RP105 is enhanced in the presence of MD1 (605241) and that expression of RP105 is restricted to CD19 (107265)-positive B cells. Immunohistochemistry showed that RP105 is expressed mainly on mature B cells in mantle zones; germinal centers were either dull or negative.
Miura et al. (1996) used fluorescence in situ hybridization to map the LY64 locus to human chromosome 5q12. They used interspecific backcross analysis to map the mouse Ly64 gene to the distal region of chromosome 13, linked to the Dhfr and Ctla3 loci.
Miura, Y., Miyake, K., Yamashita, Y., Shimazu, R., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Inazawa, J., Abe, T., Kimoto, M. Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64). Genomics 38: 299-304, 1996. [PubMed: 8975706] [Full Text: https://doi.org/10.1006/geno.1996.0632]
Miura, Y., Shimazu, R., Miyake, K., Akashi, S., Ogata, H., Yamashita, Y., Narisawa, Y., Kimoto, M. RP105 is associated with MD-1 and transmits an activation signal in human B cells. Blood 92: 2815-2822, 1998. [PubMed: 9763566]