Alternative titles; symbols
HGNC Approved Gene Symbol: OVOL1
Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,787,063-65,797,214 (from NCBI)
A critical role in Drosophila oogenesis and germline sex differentiation is played by ovo, a female germline-specific nuclear protein. Chidambaram et al. (1997) noted that homozygous ovo mutants result in female germ cell degeneration and revertants of dominant ovo mutations can result in shaven baby (svb) and lozenge-like (lzl) phenotypes that affect cuticle (epidermal/locomotor) and eye (sensory) development, respectively, suggesting a tight structural link between ovo and svb. Human OVOL1, which contains an open reading frame with zinc finger domains, is similar to Drosophila ovo and is conserved in C. elegans as well. An EST database search suggested the presence of ovo-related sequences in both the mouse and the human genome.
The human OVOL1 gene maps to 11q13, less than 200 kb proximal to the oncogene SEA (165110) (Debelenko et al., 1997). Comparative mapping data indicated that the mouse Ovol1 locus is located on MMU 19.
Chidambaram, A., Allikmets, R., Chandrasekarappa, S., Guru, S. C., Modi, W., Gerrard, B., Dean, M. Characterization of a human homolog (OVOL1) of the Drosophila ovo gene, which maps to chromosome 11q13. Mammalian Genome 8: 950-951, 1997. [PubMed: 9383297] [Full Text: https://doi.org/10.1007/s003359900620]
Debelenko, L. V., Emmert-Buck, M. R., Manickam, P., Kester, M.-B., Guru, S. C., DiFranco, E. M., Olufemi, S.-E., Agarwal, S., Lubensky, I. A., Zhuang, Z., Burns, A. L., Spiegel, A. M., Liotta, L. A., Collins, F. S., Marx, S. J., Chandrasekharappa, S. C. Haplotype analysis defines a minimum interval for the multiple endocrine neoplasia type 1 (MEN1) gene. Cancer Res. 57: 1039-1042, 1997. [PubMed: 9067266]