Alternative titles; symbols
HGNC Approved Gene Symbol: STAC
Cytogenetic location: 3p22.3-p22.2 Genomic coordinates (GRCh38): 3:36,380,504-36,548,007 (from NCBI)
RLGS-M (restriction landmark genomic scanning using methylation-sensitive endonuclease) is a method for scanning the methylation status of large sections of a genome. Using RLGS-M to scan mouse brain genomic DNA from various developmental stages, Suzuki et al. (1996) found a tissue-specific gel spot whose intensity changed developmentally. The gene corresponding to this spot, which they termed Stac (for Src homology-3 and cysteine-rich domains), encodes a predicted 403-amino acid protein. The mouse Stac gene was used to clone human STAC from a fetal brain cDNA library. The predicted 402-amino acid STAC protein is 83% identical to that of mouse. Suzuki et al. (1996) noted that cysteine-rich and SH3 domains are frequently found in signal transduction proteins, and suggested that STAC may play a role in the neuron-specific signal transduction pathway.
Kawai et al. (1998) mapped the human STAC gene to chromosome 3p24-p22 using PCR of a radiation hybrid panel. The mouse Stac gene was mapped by interspecific backcross analysis to the distal portion of chromosome 9 in a region syntenic with human chromosome 3p21.
Kawai, J., Suzuki, H., Hara, A., Hirose, K., Watanabe, S. Human and mouse chromosomal mapping of Stac, a neuron-specific protein with an SH3 domain. Genomics 47: 140-142, 1998. [PubMed: 9465308] [Full Text: https://doi.org/10.1006/geno.1997.5107]
Suzuki, H., Kawai, J., Taga, C., Yaoi, T., Hara, A., Hirose, K., Hayashizaki, Y., Watanabe, S. Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains. Biochem. Biophys. Res. Commun. 229: 902-909, 1996. [PubMed: 8954993] [Full Text: https://doi.org/10.1006/bbrc.1996.1900]