HGNC Approved Gene Symbol: PAFAH2
Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:25,959,767-25,998,063 (from NCBI)
Hattori et al. (1996) reported the cloning of a novel isoform of platelet-activating factor (PAF) acetylhydrolase (AH), termed PAFAH2 by the authors, from human tissue. PAFAH2 encodes a 392-amino acid polypeptide with a predicted mass of approximately 43 kD. Other PAF acetylhydrolases include the isoform found in plasma (PAFAH; 601690) and isoform Ib (PAFAH1B1; 601545), which is found in brain and is associated with lissencephaly (607432). Hattori et al. (1996) found that PAFAH2 shares approximately 43% identity with plasma PAFAH, but has virtually no similarity to brain PAFAH1B1. Unlike PAFAH, PAFAH2 contains no secretory signal sequence, confirming its intracellular localization. Northern blot analysis of bovine tissue revealed that PAFAH2 is expressed at highest level in liver and at lower levels in a variety of other tissues.
Gross (2014) mapped the PAFAH2 gene to chromosome 1p36.11 based on an alignment of the PAFAH2 sequence (GenBank BC001158) with the genomic sequence (GRCh37).
Gross, M. B. Personal Communication. Baltimore, Md. 4/15/2014.
Hattori, K., Adachi, H., Matsuzawa, A., Yamamoto, K., Tsujimoto, M., Aoki, J., Hattori, M., Arai, H., Inoue, K. cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II: its homology with plasma PAF acetylhydrolase. J. Biol. Chem. 271: 33032-33038, 1996. [PubMed: 8955149] [Full Text: https://doi.org/10.1074/jbc.271.51.33032]