Alternative titles; symbols
HGNC Approved Gene Symbol: SNAPC3
Cytogenetic location: 9p22.3 Genomic coordinates (GRCh38): 9:15,422,876-15,466,735 (from NCBI)
SNAPC3 encodes a subunit of the snRNA-activating protein complex (SNAPc), which is required for transcription of both RNA polymerase II and III snRNA genes (see SNAPC1, 600591) (Henry et al., 1996).
Henry et al. (1996) identified the gene for the 50-kD subunit of SNAPc based on partial sequence from the purified protein. The predicted 411-amino acid protein, designated SNAP50, is highly charged (pI = 4.9), and has 2 potential zinc finger domains.
Henry et al. (1996) used anti-SNAP50 antibodies in immunoprecipitation and in vitro transcription studies to demonstrate that SNAP50 is part of SNAPc and is required for RNA polymerase II and III snRNA gene transcription. UV crosslinking studies suggested that SNAP50 is in close proximity to the DNA when SNAPc is bound to the proximal sequence element (PSE) of the promoter.
Gross (2014) mapped the SNAPC3 gene to chromosome 9p22.3 based on an alignment of the SNAPC3 sequence (GenBank BC108743) with the genomic sequence (GRCh37).
Gross, M. B. Personal Communication. Baltimore, Md. 4/16/2014.
Henry, R. W., Ma, B., Sadowski, C. L., Kobayashi, R., Hernandez, N. Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAP(c). EMBO J. 15: 7129-7136, 1996. [PubMed: 9003788]