HGNC Approved Gene Symbol: GML
Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:142,834,801-142,846,851 (from NCBI)
Furuhata et al. (1996) identified a gene encoding a predicted 158-amino acid protein that is induced by p53 (191170). Because of its homology to glycosylphosphatidylinositol (GPI)-anchored membrane proteins, Furuhata et al. (1996) designated the gene 'GPI-anchored molecule-like protein,' or GML. By Northern blot and RT-PCR analysis, Furuhata et al. (1996) found that GML is expressed as a less than 1-kb mRNA in many tissues, including testis. Expression of GML suppressed the growth of esophageal cancer cells in culture. Furuhata et al. (1996) suggested that GML may play a role in the apoptotic pathway or cell cycle regulation induced by p53 after DNA damage.
Kimura et al. (1997) found that the GML gene consists of 4 exons spanning 12 kb, with a p53-binding site 19 kb upstream of the first exon.
Kimura et al. (1997) used fluorescence in situ hybridization to map the GML gene to 8q24.3, a region containing E48 (606204) and RIGE (601384), 2 other GPI-anchored molecule family members.
Furuhata, T., Tokino, T., Urano, T., Nakamura, Y. Isolation of a novel GPI-anchored gene specifically regulated by p53; correlation between its expression and anti-cancer drug sensitivity. Oncogene 13: 1965-1970, 1996. [PubMed: 8934543]
Kimura, Y., Furuhata, T., Urano, T., Hirata, K., Nakamura, Y., Tokino, T. Genomic structure and chromosomal localization of GML (GPI-anchored molecule-like protein), a gene induced by p53. Genomics 41: 477-480, 1997. [PubMed: 9169150] [Full Text: https://doi.org/10.1006/geno.1997.4680]