Entry - *602374 - CALPONIN 3; CNN3 - OMIM

 
 
* 602374

CALPONIN 3; CNN3


Alternative titles; symbols

CALPONIN, ACIDIC


HGNC Approved Gene Symbol: CNN3

Cytogenetic location: 1p21.3     Genomic coordinates (GRCh38): 1:94,896,957-94,927,110 (from NCBI)


TEXT

▼ Cloning and Expression

Maguchi et al. (1995) isolated a cDNA encoding calponin-3 (CNN3) by screening a human kidney cDNA library with a rat Cnn3 cDNA. The 329-amino acid CNN3 has a predicted pI of 5.64; it contains a markedly acidic C terminus with a predicted pI of 3.51. The N termini of CNN3 and CNN1 (600806) are highly homologous and basic. CNN3 contains a motif that is tandemly repeated 3 times and is similar to the repeated motif present in CNN1 and CNN2 (602373). Northern blot analysis of human RNAs showed that CNN3 is expressed in both smooth muscle and nonmuscle tissues. Maguchi et al. (1995) suggested that CNN3 is associated with the cytoskeleton but is not involved in contraction.


▼ Mapping

By FISH analysis, Maguchi et al. (1995) mapped the CNN3 gene to chromosome 1p22-p21.


▼ REFERENCES

  1. Maguchi, M., Nishida, W., Kohara, K., Kuwano, A., Kondo, I., Hiwada, K. Molecular cloning and gene mapping of human basic and acidic calponins. Biochem. Biophys. Res. Commun. 217: 238-244, 1995. [PubMed: 8526917, related citations] [Full Text]


Creation Date:
Patti M. Sherman : 2/20/1998
Edit History:
wwang : 12/09/2010
dholmes : 2/20/1998

* 602374

CALPONIN 3; CNN3


Alternative titles; symbols

CALPONIN, ACIDIC


HGNC Approved Gene Symbol: CNN3

Cytogenetic location: 1p21.3     Genomic coordinates (GRCh38): 1:94,896,957-94,927,110 (from NCBI)


TEXT

Cloning and Expression

Maguchi et al. (1995) isolated a cDNA encoding calponin-3 (CNN3) by screening a human kidney cDNA library with a rat Cnn3 cDNA. The 329-amino acid CNN3 has a predicted pI of 5.64; it contains a markedly acidic C terminus with a predicted pI of 3.51. The N termini of CNN3 and CNN1 (600806) are highly homologous and basic. CNN3 contains a motif that is tandemly repeated 3 times and is similar to the repeated motif present in CNN1 and CNN2 (602373). Northern blot analysis of human RNAs showed that CNN3 is expressed in both smooth muscle and nonmuscle tissues. Maguchi et al. (1995) suggested that CNN3 is associated with the cytoskeleton but is not involved in contraction.


Mapping

By FISH analysis, Maguchi et al. (1995) mapped the CNN3 gene to chromosome 1p22-p21.


REFERENCES

  1. Maguchi, M., Nishida, W., Kohara, K., Kuwano, A., Kondo, I., Hiwada, K. Molecular cloning and gene mapping of human basic and acidic calponins. Biochem. Biophys. Res. Commun. 217: 238-244, 1995. [PubMed: 8526917] [Full Text: https://doi.org/10.1006/bbrc.1995.2769]


Creation Date:
Patti M. Sherman : 2/20/1998

Edit History:
wwang : 12/09/2010
dholmes : 2/20/1998



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 29, 2024