Entry - *602387 - RNA-BINDING MOTIF PROTEIN, SINGLE STRAND-INTERACTING, 2; RBMS2 - OMIM

 
 
* 602387

RNA-BINDING MOTIF PROTEIN, SINGLE STRAND-INTERACTING, 2; RBMS2


Alternative titles; symbols

SCR3


HGNC Approved Gene Symbol: RBMS2

Cytogenetic location: 12q13.3     Genomic coordinates (GRCh38): 12:56,520,405-56,596,193 (from NCBI)


TEXT

▼ Cloning and Expression

Kanaoka and Nojima (1994) isolated 2 multicopy suppressors of yeast cdc2 kinase and cdc13 cyclin mutants, and designated them SCR2 (602310) and SCR3. SCR3 encodes a predicted 407-amino acid protein with 2 RNA-binding motifs. Kanaoka and Nojima (1994) suggested that SCR3 suppresses cdc2 kinase and cdc13 cyclin mutants through the induction of translation of cdc2. On Northern blots, SCR3 was expressed as multiple mRNAs in most cell lines tested, but not in HeLa.


▼ Mapping

Gross (2014) mapped the RBMS2 gene to chromosome 12q13.3 based on an alignment of the RBMS2 sequence (GenBank BC072679) with the genomic sequence (GRCh38).

▼ REFERENCES

  1. Gross, M. B. Personal Communication. Baltimore, Md. 8/29/2014.

  2. Kanaoka, Y., Nojima, H. SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins. Nucleic Acids Res. 22: 2687-2693, 1994. [PubMed: 8041632, related citations] [Full Text]


Contributors:
Matthew B. Gross - updated : 08/29/2014
Creation Date:
Rebekah S. Rasooly : 2/24/1998
Edit History:
mgross : 08/29/2014
carol : 4/15/2014
mgross : 3/28/2001
alopez : 2/23/2000
alopez : 2/24/1998

* 602387

RNA-BINDING MOTIF PROTEIN, SINGLE STRAND-INTERACTING, 2; RBMS2


Alternative titles; symbols

SCR3


HGNC Approved Gene Symbol: RBMS2

Cytogenetic location: 12q13.3     Genomic coordinates (GRCh38): 12:56,520,405-56,596,193 (from NCBI)


TEXT

Cloning and Expression

Kanaoka and Nojima (1994) isolated 2 multicopy suppressors of yeast cdc2 kinase and cdc13 cyclin mutants, and designated them SCR2 (602310) and SCR3. SCR3 encodes a predicted 407-amino acid protein with 2 RNA-binding motifs. Kanaoka and Nojima (1994) suggested that SCR3 suppresses cdc2 kinase and cdc13 cyclin mutants through the induction of translation of cdc2. On Northern blots, SCR3 was expressed as multiple mRNAs in most cell lines tested, but not in HeLa.


Mapping

Gross (2014) mapped the RBMS2 gene to chromosome 12q13.3 based on an alignment of the RBMS2 sequence (GenBank BC072679) with the genomic sequence (GRCh38).

REFERENCES

  1. Gross, M. B. Personal Communication. Baltimore, Md. 8/29/2014.

  2. Kanaoka, Y., Nojima, H. SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins. Nucleic Acids Res. 22: 2687-2693, 1994. [PubMed: 8041632] [Full Text: https://doi.org/10.1093/nar/22.13.2687]


Contributors:
Matthew B. Gross - updated : 08/29/2014

Creation Date:
Rebekah S. Rasooly : 2/24/1998

Edit History:
mgross : 08/29/2014
carol : 4/15/2014
mgross : 3/28/2001
alopez : 2/23/2000
alopez : 2/24/1998



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 6, 2024