HGNC Approved Gene Symbol: KCNA10
Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,517,217-110,519,175 (from NCBI)
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Present in all eukaryotic cells, their diverse functions include maintaining membrane potential, regulating cell volume, and modulating electrical excitability in neurons. The delayed rectifier function of potassium channels allows nerve cells to efficiently repolarize following an action potential. In Drosophila, 4 sequence-related K+ channel genes--Shaker, Shaw, Shab, and Shal--have been identified. Each has been shown to have a human homolog (Chandy et al., 1990; McPherson et al., 1991).
KCNA10 represents a novel class of K channel specifically regulated by cGMP (summary by Orias et al., 1997).
Orias et al. (1997) cloned the human homolog of rabbit KCNA10, a gene encoding a Shaker-related potassium-selective channel specifically regulated by cGMP. Human KCNA10, encoding a deduced 511-amino acid protein, is 85% identical to the rabbit protein.
Orias et al. (1997) used fluorescence in situ hybridization and PCR of YACs to map the KCNA10 gene to 1p13.1, a region that also contains KCNA3 (176263).
Chandy, K. G., Williams, C. B., Spencer, R. H., Aguilar, B. A., Ghanshani, S., Tempel, B. L., Gutman, G. A. A family of three mouse potassium channel genes with intronless coding regions. Science 247: 973-975, 1990. [PubMed: 2305265] [Full Text: https://doi.org/10.1126/science.2305265]
McPherson, J. D., Wasmuth, J. J., Chandy, K. G., Swanson, R., Dethlefs, B., Chandy, G., Wymore, R., Ghanshani, S. Chromosomal localization of 7 potassium channel genes. (Abstract) Cytogenet. Cell Genet. 58: 1979, 1991.
Orias, M., Bray-Ward, P., Curran, M. E., Keating, M. T., Desir, G. V. Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. Genomics 42: 33-37, 1997. [PubMed: 9177773] [Full Text: https://doi.org/10.1006/geno.1997.4712]