HGNC Approved Gene Symbol: UVRAG
Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:75,815,210-76,144,232 (from NCBI)
Teitz et al. (1990) identified a cDNA that partially complements the ultraviolet (UV) sensitivity of xeroderma pigmentosum complementation group C (278720) cells. Perelman et al. (1997) named this gene 'UV radiation resistance-associated gene' (UVRAG) and reported that the 4.0 kb UVRAG mRNA encodes a predicted 648-amino acid protein. Using cell fractionation studies, they found that the UVRAG protein either is localized within an organelle or is part of the cytoskeleton. Northern blot analysis showed that UVRAG is expressed ubiquitously in humans; it was also present in most of the vertebrate species tested.
By fluorescence in situ hybridization and PCR analysis of somatic cell hybrids, Perelman et al. (1997) mapped the UVRAG gene to chromosome 11q13, between D11S916 and D11S906.
Perelman, B., Dafni, N., Naiman, T., Eli, D., Yaakov, M., Yang Feng, T. L., Sinha, S., Weber, G., Khodaei, S., Sancar, A., Dotan, I., Canaani, D. Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus. Genomics 41: 397-405, 1997. [PubMed: 9169138] [Full Text: https://doi.org/10.1006/geno.1997.4623]
Teitz, T., Penner, M., Eli, D., Stark, M., Bakhanashvili, M., Naiman, T., Canaani, D. Isolation by polymerase chain reaction of a cDNA whose product partially complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells. Gene 87: 295-298, 1990. [PubMed: 2332174] [Full Text: https://doi.org/10.1016/0378-1119(90)90316-j]