Alternative titles; symbols
HGNC Approved Gene Symbol: CCL23
Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:36,013,058-36,017,972 (from NCBI)
Chemokines are a family of small cytokines that stimulate proinflammatory activity by attracting leukocytes. Beta-chemokines, such as CCL23, are characterized by a CC motif (2 contiguous cysteines) (Patel et al., 1997).
Patel et al. (1997) identified 2 beta-chemokines by searching ESTs for conserved beta-chemokine motifs and designated them MPIF1 and MPIF2 (602495). MPIF1 encodes a predicted 120-amino acid protein that contains a 21-amino acid N-terminal signal peptide. The MPIF1 protein, which migrates as a 11- to 12-kD band on SDS-PAGE, is 51% identical to that of MIP1-alpha (182283). Northern blot analysis detected a 0.8-kb MPIF1 mRNA that was most abundant in adult lung and liver, with lower levels in adult bone marrow and placenta and in fetal liver. It was also expressed in myelomonocytic cell lines.
Patel et al. (1997) found that MPIF1 had chemotactic activity on resting T lymphocytes and monocytes and lower activity on neutrophils. MPIF1 also inhibited, in vitro, hematopoietic progenitor cells that give rise to granulocyte and monocyte lineages.
Gross (2014) mapped the CCL23 gene to chromosome 17q12 based on an alignment of the CCL23 sequence (GenBank BC093970) with the genomic sequence (GRCh37).
Gross, M. B. Personal Communication. Baltimore, Md. 4/16/2014.
Patel, V. P., Kreider, B. L., Li, Y., Li, H., Leung, K., Salcedo, T., Nardelli, B., Pippalla, V., Gentz, S., Thotakura, R., Parmelee, D., Gentz, R., Garotta, G. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. J. Exp. Med. 185: 1163-1172, 1997. [PubMed: 9104803] [Full Text: https://doi.org/10.1084/jem.185.7.1163]