HGNC Approved Gene Symbol: RGS7
Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:240,774,742-241,357,230 (from NCBI)
To study genes involved in the neural control of egg laying, Koelle and Horvitz (1996) cloned the egl-10 gene from C. elegans. Mutations in the egl-10 gene result in a phenotype opposite to that caused by mutations in the G protein gene goa-1, suggesting that EGL-10 may regulate a G protein signaling pathway. Koelle and Horvitz (1996) found that EGL-10 shares a region of homology with yeast Sst2p, which regulates G protein signaling, so they named the common domain 'RGS' for 'regulator of G protein signaling similarity domain'. The authors noted that several other proteins, including human RGS1 (600323) and RGS2 (600861), contain this domain. They identified additional human genes encoding the RGS domain by searching a database of expressed sequence tags (ESTs). They cloned a partial 1.9-kb cDNA, designated RGS7, that contains a 420-codon open reading frame encoding a protein with 53% identity to EGL-10. The homology between RGS7 and EGL-10 extends beyond the RGS domain. Northern blotting of rat mRNA showed that RGS7 is expressed primarily in brain, with lower levels in lung, as a 2.7-kb mRNA.
Sierra et al. (2002) determined that the RGS7 gene contains 16 exons and spans more than 110 kb.
By genomic sequence analysis, Sierra et al. (2002) mapped the RGS7 gene to chromosome 1q23.1. However, Gross (2011) mapped the RGS7 gene to chromosome 1q43 based on an alignment of the RGS7 sequence (GenBank BC022009) and the genomic sequence (GRCh37).
Sierra et al. (2002) mapped the mouse Rgs7 gene to chromosome 1 by interspecific backcross mapping.
Gross, M. B. Personal Communication. Baltimore, Md. 4/20/2011.
Koelle, M. R., Horvitz, H. R. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Cell 84: 115-125, 1996. [PubMed: 8548815] [Full Text: https://doi.org/10.1016/s0092-8674(00)80998-8]
Sierra, D. A., Gilbert, D. J., Householder, D., Grishin, N. V., Yu, K., Ukidwe, P., Barker, S. A., He, W., Wensel, T. G., Otero, G., Brown, G., Copeland, N. G., Jenkins, N. A., Wilkie, T. M. Evolution of the regulators of G-protein signaling multigene family in mouse and human. Genomics 79: 177-185, 2002. [PubMed: 11829488] [Full Text: https://doi.org/10.1006/geno.2002.6693]