Entry - *602683 - ADHESION G PROTEIN-COUPLED RECEPTOR B2; ADGRB2 - OMIM

 
 
* 602683

ADHESION G PROTEIN-COUPLED RECEPTOR B2; ADGRB2


Alternative titles; symbols

BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 2; BAI2


HGNC Approved Gene Symbol: ADGRB2

Cytogenetic location: 1p35.2     Genomic coordinates (GRCh38): 1:31,727,117-31,764,340 (from NCBI)


TEXT

▼ Cloning and Expression

Shiratsuchi et al. (1997) identified 2 novel human genes homologous to BAI1 (608682), an angiogenesis inhibitor that is a candidate for involvement in development of glioblastoma. Like BAI1, these 2 genes, designated BAI2 and BAI3 (602684), were specifically expressed in brain, and are likely to be expressed in the same type of cells. However, in spite of similar tissue specificity among the 3 BAI genes, only BAI1 is transcriptionally regulated by p53.


▼ Mapping

Shiratsuchi et al. (1997) mapped the BAI2 gene to 1p35 by fluorescence in situ hybridization.


▼ REFERENCES

  1. Shiratsuchi, T., Nishimori, H., Ichise, H., Nakamura, Y., Tokino, T. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). Cytogenet. Cell Genet. 79: 103-108, 1997. [PubMed: 9533023, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 6/3/1998
Edit History:
mgross : 08/31/2016
carol : 06/11/2012
carol : 6/3/1998

* 602683

ADHESION G PROTEIN-COUPLED RECEPTOR B2; ADGRB2


Alternative titles; symbols

BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 2; BAI2


HGNC Approved Gene Symbol: ADGRB2

Cytogenetic location: 1p35.2     Genomic coordinates (GRCh38): 1:31,727,117-31,764,340 (from NCBI)


TEXT

Cloning and Expression

Shiratsuchi et al. (1997) identified 2 novel human genes homologous to BAI1 (608682), an angiogenesis inhibitor that is a candidate for involvement in development of glioblastoma. Like BAI1, these 2 genes, designated BAI2 and BAI3 (602684), were specifically expressed in brain, and are likely to be expressed in the same type of cells. However, in spite of similar tissue specificity among the 3 BAI genes, only BAI1 is transcriptionally regulated by p53.


Mapping

Shiratsuchi et al. (1997) mapped the BAI2 gene to 1p35 by fluorescence in situ hybridization.


REFERENCES

  1. Shiratsuchi, T., Nishimori, H., Ichise, H., Nakamura, Y., Tokino, T. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). Cytogenet. Cell Genet. 79: 103-108, 1997. [PubMed: 9533023] [Full Text: https://doi.org/10.1159/000134693]


Creation Date:
Victor A. McKusick : 6/3/1998

Edit History:
mgross : 08/31/2016
carol : 06/11/2012
carol : 6/3/1998



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 28, 2024